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> inhibiting insulin signalling can delay ageing and extend lifespan in many animals Does this mean that the newer diet medications like Semaglutide could be a
by aantix 4y ago
> inhibiting insulin signalling can delay ageing and extend lifespan in many animals
Does this mean that the newer diet medications like Semaglutide could be accelerating aging since they increase the secretion of insulin from the beta cells?
- tempsy 4y agoYeah interesting question, though losing weight via caloric restriction is probably still a big positive effect
- rybosworld 4y agoIt's also associated with thyroid tumors so I'd consider it a life shortener for that alone.
- ericb 4y agoThat so far hasn't been documented in humans. Also, being overweight is a life shortener itself, so the question is just which is riskier on-balance.
- hammyhavoc 4y agoFuck me, I hadn't heard about these. Those are some scary side effects.
- 6177c40f 4y agoUnclear, but some really preliminary research suggests it might actually neuroprotective [1] and cardioprotective [2]. A lot more research needs to be done though, it seems. [1] https://pubmed.ncbi.nlm.nih.gov/36191807/ https://pubmed.ncbi.nlm.nih.gov/36191807/ [2] https://pubmed.ncbi.nlm.nih.gov/36515811/ https://pubmed.ncbi.nlm.nih.gov/36515811/