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Can we modify the oral vaccine (virus) to be more resistant to mutation? Specifically, I'm thinking there is a lot of redundancy in the codon table - mapping tr
by phkahler 4y ago
Can we modify the oral vaccine (virus) to be more resistant to mutation? Specifically, I'm thinking there is a lot of redundancy in the codon table - mapping triplets to amino acids. If we increase the levenshtein distance between the vaccine-virus and the bad one without changing its protein structure it should reduce the likelihood of reverting back in the wild.
- btilly 4y agoWe tried that. It reduced the frequency with which it happens, but not as much as we would like. https://www.science.org/content/article/first-polio-cases-linked-new-oral-vaccine-detected-africa https://www.science.org/content/article/first-polio-cases-li...