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I don't think OP it's saying they are not important just that their names get used so much that they lose all meaning. Both schizophrenia and depression are li

I don't think OP it's saying they are not important just that their names get used so much that they lose all meaning. Both schizophrenia and depression are linked to dopamine and serotonin limiting our understanding of the diseases to has more or less of x neurotransmitter is naive. Same with chronic stress and cortisol and probably ADHD and dopamine. The problem is trying to explain every single thing using the same neurotransmitters and nothing else while just serotonin alone can make you puke your guts out or see god (god meaning: whatever you believe in) or alter your sleep.

LoganDark 4y ago
> Both schizophrenia and depression are linked to dopamine and serotonin limiting our understanding of the diseases to has more or less of x neurotransmitter is naive. Same with chronic stress and cortisol and probably ADHD and dopamine. > The problem is trying to explain every single thing using the same neurotransmitters and nothing else while just serotonin alone can make you puke your guts out or see god (god meaning: whatever you believe in) or alter your sleep. Yeah, I see your point. I just don't think it's fair to go on a whole spiel about how a "dopamine system" doesn't even exist when there are obvious examples of people who have defects in that system that cause a whole host of issues. Yeah sure the correct term is "dopaminergic system", but... does it really matter? (Not to mention that dopamine is the primary reward response for "doing things you enjoy" anyway, so it's even relevant in this context. Even if you want to get technical and say endorphins are responsible for some of it...)
- scythe 4y ago
  >I just don't think it's fair to go on a whole spiel about how a "dopamine system" doesn't even exist Because it does not exist. The correct term is not "dopaminergic system". There is no system associated to any particular neurotransmitter. >Not to mention that dopamine is the primary reward response for "doing things you enjoy" It is not. Dopamine is a neurotransmitter that is used by neurons involved in reward circuits. The reward response consists of actual neuronal activation, not levels of extracellular neurotransmitters.
  - LoganDark 4y ago
    > Because it does not exist. The correct term is not "dopaminergic system". There is no system associated to any particular neurotransmitter. The "dopaminergic system" is literally just the pathways that contain those neurotransmitters. I just finished a reply to one of your other comments that contains more info on this, but it does exist. > Dopamine is a neurotransmitter that is used by neurons involved in reward circuits. The reward response consists of actual neuronal activation, not levels of extracellular neurotransmitters. Oops, nice catch. I'll give you this one because I did not know that actually. Still, a dopamine deficiency prevents reward circuits from being activated as much (or at all), if there's nothing to transmit it. This can contribute to executive dysfunction (which can cause ADHD).

LoganDark 4y ago

> Both schizophrenia and depression are linked to dopamine and serotonin limiting our understanding of the diseases to has more or less of x neurotransmitter is naive. Same with chronic stress and cortisol and probably ADHD and dopamine. > The problem is trying to explain every single thing using the same neurotransmitters and nothing else while just serotonin alone can make you puke your guts out or see god (god meaning: whatever you believe in) or alter your sleep. Yeah, I see your point. I just don't think it's fair to go on a whole spiel about how a "dopamine system" doesn't even exist when there are obvious examples of people who have defects in that system that cause a whole host of issues. Yeah sure the correct term is "dopaminergic system", but... does it really matter? (Not to mention that dopamine is the primary reward response for "doing things you enjoy" anyway, so it's even relevant in this context. Even if you want to get technical and say endorphins are responsible for some of it...)

scythe 4y ago
>I just don't think it's fair to go on a whole spiel about how a "dopamine system" doesn't even exist Because it does not exist. The correct term is not "dopaminergic system". There is no system associated to any particular neurotransmitter. >Not to mention that dopamine is the primary reward response for "doing things you enjoy" It is not. Dopamine is a neurotransmitter that is used by neurons involved in reward circuits. The reward response consists of actual neuronal activation, not levels of extracellular neurotransmitters.
- LoganDark 4y ago
  > Because it does not exist. The correct term is not "dopaminergic system". There is no system associated to any particular neurotransmitter. The "dopaminergic system" is literally just the pathways that contain those neurotransmitters. I just finished a reply to one of your other comments that contains more info on this, but it does exist. > Dopamine is a neurotransmitter that is used by neurons involved in reward circuits. The reward response consists of actual neuronal activation, not levels of extracellular neurotransmitters. Oops, nice catch. I'll give you this one because I did not know that actually. Still, a dopamine deficiency prevents reward circuits from being activated as much (or at all), if there's nothing to transmit it. This can contribute to executive dysfunction (which can cause ADHD).