4 ms·

Pure Meth isn't that much different than Adderall, and ~7% of the population is using Adderall... Adderall users are doing all kind of productive things in soc

Pure Meth isn't that much different than Adderall, and ~7% of the population is using Adderall... Adderall users are doing all kind of productive things in society. Why can't Meth users?

junofan 4y ago
7% seems high. Googling shows ~40 million prescriptions dispensed in 2021. Since CSA disallows refills and 90-day fills are extremely rare, that’s about 40/12=3 million patients, or roughly 1–2%.
fauxpause_ 4y ago
I would be curious if other knowledgeable folks agree that pure meth isn’t that much different from Adderall on dimensions that are likely to be relevant.
- boomboomsubban 4y ago
  There's another ADHD medicine called Desoxyn which is methamphetamine. Adderal is a mix of amphetamine salts, but it's still fair to say they're not very different. The main difference is in the common dosage.
- CommitSyn 4y ago
  Adderall will have me overly focusing on one thing if I take a bit too much. Meth will have me sitting at the computer for 8 hours knowing I have other obligations if I take a bit too much. I'm also much more distracted and likely to hop to new random things on meth, versus hyper focusing on one thing.
- fwlr 4y ago
  “Methamphetamine (meth) is a stimulant. The FDA- approved brand-name medication is Desoxyn®.” https://www.dea.gov/sites/default/files/2020-06/Methamphetamine-2020_0.pdf https://www.dea.gov/sites/default/files/2020-06/Methamphetam... (pdf) Adderall is regular (non-methylated) amphetamine, specifically a mixture of levo-amphetamine and dextro-amphetamine. There are minor differences in effect profile between methamphetamine and amphetamine, the biggest of these minor differences being in neuroprotectivity (it’s been a while since I’ve done the research but iirc amphetamine is mildly neuroprotective while meth is neutral or mildly negative, due to meth interrupting some metabolizing process). The major difference is that milligram-for-milligram, meth is 2-5x more potent than regular amphetamine. The perception that they are very different is valid, though, because amphetamine is usually consumed therapeutically (lower doses, guaranteed purity, controlled dosing schedule, safer administration route) while meth is usually consumed recreationally (higher doses, unknown and often dubious purity, erratic dosing schedule, riskier administration routes). Injecting a quarter of a gram of street meth over a three day binge is much more harmful than taking 40mg Adderall extended release formulation by mouth every morning.
- fsociety 4y ago
  tldr; pretty different in practice, trust your doctor, all that good stuff. On some level, it is similar as they are both stimulants and nearly the same chemical. But my own research suggests the methyl group has a significant effect on how the body metabolizes the drug. The methyl group makes it fat-soluble which allows it to cross the blood brain barrier. Apparently this causes it to have an effect on dopamine and serotonin receptors which it would otherwise not - hence the euphoric effect. It also cleaves into amphetamine in the blood stream which gives it a significantly higher half-life. How you administer a drug is important, which is self explanatory. Most newer ADHD stimulants are made in such that they must be metabolized through the stomach. Additionally, the dosage is important. Meth is not only more potent, but when abused is likely to be taken in 10x (or more) amount than a therapeutic dose. So.. safe to say they are chemically similar but different in practice. This info is from my quick googling. I’m on a therapeutic dose of Adderall, and given its effect on my blood pressure I would be concerned taking meth due to all of the above. And this is why I have a doctor to help me with all of this.
tgv 4y ago
Gasoline is not that much different from kerosine. Planes fly, why can't cars?
- onlyrealcuzzo 4y ago
  [flagged]
tyingq 4y ago
Adderall generally comes in a fixed quantity of lower potency than meth, and in beads designed to spread the release out over time. It's supposedly not easy to smoke it either. Then there's just the nature of addiction. Some people seem predisposed to it. The Vietnam war is a good example. High percentage of heroin use there by US soldiers, but a much smaller percentage of the in-country users returned home with a habit. Another example is the high occurrence of addiction following bariatric surgery, with people who didn't have the issue prior.

Pure Meth isn't that much different than Adderall, and ~7% of the population is using Adderall... Adderall users are doing all kind of productive things in society. Why can't Meth users?

junofan 4y ago

7% seems high. Googling shows ~40 million prescriptions dispensed in 2021. Since CSA disallows refills and 90-day fills are extremely rare, that’s about 40/12=3 million patients, or roughly 1–2%.

fauxpause_ 4y ago

I would be curious if other knowledgeable folks agree that pure meth isn’t that much different from Adderall on dimensions that are likely to be relevant.

boomboomsubban 4y ago
There's another ADHD medicine called Desoxyn which is methamphetamine. Adderal is a mix of amphetamine salts, but it's still fair to say they're not very different. The main difference is in the common dosage.
CommitSyn 4y ago
Adderall will have me overly focusing on one thing if I take a bit too much. Meth will have me sitting at the computer for 8 hours knowing I have other obligations if I take a bit too much. I'm also much more distracted and likely to hop to new random things on meth, versus hyper focusing on one thing.
fwlr 4y ago
“Methamphetamine (meth) is a stimulant. The FDA- approved brand-name medication is Desoxyn®.” https://www.dea.gov/sites/default/files/2020-06/Methamphetamine-2020_0.pdf https://www.dea.gov/sites/default/files/2020-06/Methamphetam... (pdf) Adderall is regular (non-methylated) amphetamine, specifically a mixture of levo-amphetamine and dextro-amphetamine. There are minor differences in effect profile between methamphetamine and amphetamine, the biggest of these minor differences being in neuroprotectivity (it’s been a while since I’ve done the research but iirc amphetamine is mildly neuroprotective while meth is neutral or mildly negative, due to meth interrupting some metabolizing process). The major difference is that milligram-for-milligram, meth is 2-5x more potent than regular amphetamine. The perception that they are very different is valid, though, because amphetamine is usually consumed therapeutically (lower doses, guaranteed purity, controlled dosing schedule, safer administration route) while meth is usually consumed recreationally (higher doses, unknown and often dubious purity, erratic dosing schedule, riskier administration routes). Injecting a quarter of a gram of street meth over a three day binge is much more harmful than taking 40mg Adderall extended release formulation by mouth every morning.
fsociety 4y ago
tldr; pretty different in practice, trust your doctor, all that good stuff. On some level, it is similar as they are both stimulants and nearly the same chemical. But my own research suggests the methyl group has a significant effect on how the body metabolizes the drug. The methyl group makes it fat-soluble which allows it to cross the blood brain barrier. Apparently this causes it to have an effect on dopamine and serotonin receptors which it would otherwise not - hence the euphoric effect. It also cleaves into amphetamine in the blood stream which gives it a significantly higher half-life. How you administer a drug is important, which is self explanatory. Most newer ADHD stimulants are made in such that they must be metabolized through the stomach. Additionally, the dosage is important. Meth is not only more potent, but when abused is likely to be taken in 10x (or more) amount than a therapeutic dose. So.. safe to say they are chemically similar but different in practice. This info is from my quick googling. I’m on a therapeutic dose of Adderall, and given its effect on my blood pressure I would be concerned taking meth due to all of the above. And this is why I have a doctor to help me with all of this.

tgv 4y ago

Gasoline is not that much different from kerosine. Planes fly, why can't cars?

onlyrealcuzzo 4y ago
[flagged]

tyingq 4y ago

Adderall generally comes in a fixed quantity of lower potency than meth, and in beads designed to spread the release out over time. It's supposedly not easy to smoke it either. Then there's just the nature of addiction. Some people seem predisposed to it. The Vietnam war is a good example. High percentage of heroin use there by US soldiers, but a much smaller percentage of the in-country users returned home with a habit. Another example is the high occurrence of addiction following bariatric surgery, with people who didn't have the issue prior.