4 ms·

Can you name which ones? Being in the field of pharmacology, this is interesting to me. I'd love to read about it I'd you have sources

anonymouskimmer 4y ago
Desomorphine seems kind of bad, even without the other nasty effects when it is homemade by people who can't afford the real thing (i.e. Krokodil). https://en.wikipedia.org/wiki/Desomorphine https://en.wikipedia.org/wiki/Desomorphine > While desomorphine was found to be faster acting and more effective than morphine for the rapid relief of severe pain, its shorter duration of action and the relatively more severe respiratory depression produced at equianalgesic doses, as well as a high incidence of other side effects such as hypotension and urinary retention, were felt to outweigh any potential advantages.[15][16] From [15] we have: short duration which is independent of dose, tolerance, persistent decrease in respiratory rate, <when used to treat severe chronic pain> less sleep compared to morphine, possible greater withdrawal symptoms than morphine. For medical uses [15] cites some good uses where it is preferable to morphine, but this is a drug that's even more worthy of regulation than morphine itself.
- kevviiinn 4y ago
  But definitely isn't worse than alcohol and fentanyl and 6MAM are both used medically. The damage from krokodil, as you mention, is from the impurities. Not to mention, krokodil wouldn't even be a thing if people had access to the usual schedule 1 substances
  - anonymouskimmer 4y ago
    > krokodil wouldn't even be a thing if people had access to the usual schedule 1 substances ...at a price they can afford. Otherwise it still would be a thing, regardless of schedule 1 legality.
    - kevviiinn 4y ago
      One of the reasons those drugs are expensive is because of the illegality. In states with permissive cannabis laws the prices have fallen enormously. Not to mention people could easily grow poppies if it were legal to do so and extract the latex

anonymouskimmer 4y ago

Desomorphine seems kind of bad, even without the other nasty effects when it is homemade by people who can't afford the real thing (i.e. Krokodil). https://en.wikipedia.org/wiki/Desomorphine https://en.wikipedia.org/wiki/Desomorphine > While desomorphine was found to be faster acting and more effective than morphine for the rapid relief of severe pain, its shorter duration of action and the relatively more severe respiratory depression produced at equianalgesic doses, as well as a high incidence of other side effects such as hypotension and urinary retention, were felt to outweigh any potential advantages.[15][16] From [15] we have: short duration which is independent of dose, tolerance, persistent decrease in respiratory rate, <when used to treat severe chronic pain> less sleep compared to morphine, possible greater withdrawal symptoms than morphine. For medical uses [15] cites some good uses where it is preferable to morphine, but this is a drug that's even more worthy of regulation than morphine itself.

kevviiinn 4y ago
But definitely isn't worse than alcohol and fentanyl and 6MAM are both used medically. The damage from krokodil, as you mention, is from the impurities. Not to mention, krokodil wouldn't even be a thing if people had access to the usual schedule 1 substances
- anonymouskimmer 4y ago
  > krokodil wouldn't even be a thing if people had access to the usual schedule 1 substances ...at a price they can afford. Otherwise it still would be a thing, regardless of schedule 1 legality.
  - kevviiinn 4y ago
    One of the reasons those drugs are expensive is because of the illegality. In states with permissive cannabis laws the prices have fallen enormously. Not to mention people could easily grow poppies if it were legal to do so and extract the latex