Fructose is metabolized primarily in the liver. Glucose is metabolized through many other (supposedly less deleterious) processes. HFCS is primarily fructose.

Fructose is metabolized primarily in the liver. Glucose is metabolized through many other (supposedly less deleterious) processes. HFCS is primarily fructose. Refined sugar is a mix of about 50-50 fructose-glucose. Thus, refined sugar is significantly different that HFCS.