4 ms·
May I suggest that, if you have't already, you get a 23andme. "While light alcohol consumption has been associated with a decreased risk of AD in general [127],
by garyrob 4y ago
May I suggest that, if you have't already, you get a 23andme. "While light alcohol consumption has been associated with a decreased risk of AD in general [127], this relationship does not appear to hold in ApoE4 carriers. Consumption of any amount of alcohol may increase the risk of AD[Alzheimer's disease] for ApoE4 carriers [128,129,130]. In one study, both light and moderate alcohol consumption were associated with improvement in learning and memory for non-carriers, but with a decline in learning and memory for carriers [129]. Other studies found that ApoE4 carriers who consumed alcohol one or more times per month had a higher risk of AD than those who never consumed alcohol [128] and the risk of AD for carriers increased with increasing amounts of alcohol consumption [130] These data suggest that alcohol consumption should be limited, especially in ApoE4 carriers." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073598/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073598/
- mil22 4y agoThank you, that's super interesting information I wasn't aware of. I did get 23andMe back in 2009 and was able to locate the ApoE4 SNP. For anyone with 23andMe or WGS etc. and wants to do the same, look up rs7412 - the C/C combination is "normal", while one T increases your AD risk by 3x and two Ts by 10x. As it turns out, I do have one T, so I have another really good reason to avoid alcohol entirely - and also to take krill oil, quercetin, resveratrol/pterostilbene, D3, K2, the Bs, and lithium (the recommendations from the study you linked).