I liked homebrew until I needed pygtk. I don't know of any good way to install that but with macports and boy is it a pain to install without a package manager.

I liked homebrew until I needed pygtk. I don't know of any good way to install that but with macports and boy is it a pain to install without a package manager. And once I needed macports. I also like to have a recent version of gcc. This also required macports.