4 ms·

Amphetamines and methamphetamine are closely related. Methamphetamine is actually a derivative of amphetamine. So - you're wrong. And with that stupid insult y

• johnnyjeans 4y ago
  > Amphetamines and methamphetamine are closely related. In the field of biochemistry, this is virtually meaningless. A single substitution group is capable of producing wild changes in pharmacokinetics. The left and right-handed enantiomers of these molecules don't even act the same way in the body, and these aren't even positional isomers. The similarities with AMP and MAMP begin and end with being TAAR1 agonists. Off the top of my head, MAMP is also a potent agonist for sigma 1 & 2 receptors, and is generally more promiscuous. Methamphetamine is a substituted amphetamine, not a "derivative". They're both simple substituted phenylethylamines, another TAAR1 agonist that is extremely prolific in your neurochemistry as we speak, and an incredibly diverse family of monoamines that range from lethal neurotoxin to serotonergic hallucinogen. The difference between the two is often as simple as a single atom moved 2 or 3 substitution points over. When you lack basic domain knowledge, please don't call other people dumb as you try (and fail) to correct them.
  • rozal 4y ago
    Methamphetamine is not a substitution for amphetamine. A substitution refers to the replacement of one atom or group of atoms in a molecule with another atom or group of atoms. A derivative, on the other hand, refers to a molecule that is derived from another molecule by modifying its molecular structure. In the case of amphetamine and methamphetamine, methamphetamine is derived from amphetamine by adding a methyl group (-CH3) to the amphetamine molecule, which modifies its molecular structure. Amphetamines and methamphetamine are closely related drugs, as methamphetamine is a type of amphetamine. They both work in a similar way by increasing the release and blocking the reuptake of certain neurotransmitters, such as dopamine, norepinephrine, and serotonin, in the brain. As a result, they both have similar effect. All you're doing is microdosing a terrible drug and calling it treatment. Addicts defend this, not logical healthy people.
    • johnnyjeans 4y ago
      Did you write this post with a chatbot? > Methamphetamine is not a substitution for amphetamine. I did not say it was a "substitution" which means something entirely different in this context, I said it was a substituted amphetamine. The rest of this comment reads like boilerplate drivel that completely ignores everything I actually wrote.
      • rozal 4y ago
        Still causes psychosis.
• romwell 4y ago
  >Amphetamines and methamphetamine are closely related. So are ethanol (vodka) and methanol (poisonous fuel). The difference is exactly the same - one methyl group (CH3). If you think that it's a small difference, try drinking methanol instead of alcohol, and see for yourself. (Or, rather, not see for yourself, given the side effects of methanol poisoning).
  • rozal 4y ago
    Prolonged use of amphetamines can lead to addiction, psychosis, cardiovascular problems, and other serious health issues. This is the bottom line. It’s a drug, it’s not good for you. That euphoria is not treatment, your being drugged. Only addicts defend long term use
    • callalex 4y ago
      Would you say that amputees are addicted to using a chair? Or do you think that would be a bigoted thing to say?
      • rozal 4y ago
        A chair doesn't drug you and put you into psychosis. Not even the good kind of drug either.