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Boost B1/B2/B3 vitamin supplementation, take NAD boosters like Niagen or NMN, NAC, potassium and alpha-ketoglutarate to get your neural mitochondria back into s
by bitL 4y ago
Boost B1/B2/B3 vitamin supplementation, take NAD boosters like Niagen or NMN, NAC, potassium and alpha-ketoglutarate to get your neural mitochondria back into shape. Sodium-potassium pump consumes 75% of neuron's energy and too low potassium or too weak mitochondria interferes with it. Too strong mitochondria with low potassium makes it worse as well. NAC is to get rid of metabolic waste, AKG is to make cells more resilient.
- Trasmatta 4y agoSupplementation can only do so much when there are fundamental psychological issues at play too
- bitL 4y agoPsychological issues often stem from mitochondria not working properly, i.e. neurons not having enough energy to work well. Fix mitochondria and many psychological problems disappear. See e.g.: https://pubmed.ncbi.nlm.nih.gov/18979198/ https://pubmed.ncbi.nlm.nih.gov/18979198/ https://www.quantamagazine.org/mitochondria-may-hold-keys-to-anxiety-and-mental-health-20200810/ https://www.quantamagazine.org/mitochondria-may-hold-keys-to...
- tayo42 4y agowhat makes you think that your mitochondria isn't working properly. reading this it sounds like your throwing a bunch of supplements at something and hoping something else happens. it doesn't sound very scientific.
- bitL 4y agoDid you read the second link?
- tayo42 4y agoI don't think that justifies saying its often mitochondira. it doesnt explain why in the first place. it sounds like the depression is caused by an chemical imbalance thing. i dont think you can make sweeping judgements like that and say something like just take some vitamins and youll be cured
- bitL 4y agoOP talked about burnout which is seen as a lack of mental energy. Mitochondria would be the first thing to look at when it comes to energy as it's a "power plant" that makes cells work.
- tayo42 4y agoI think you should read a little of what burnout actually is instead of supplement pseudoscience
- bitL 4y agoYou are accusing me of following pseudoscience yet I am the only person in this conversation to actually post scientific links...
- tayo42 4y agoYou already expressed you don't understand what causes burnout and what experience is like. It's not just mental energy. Go read about mental health and how people actually experience. I'm not here to educate you
- dang 4y agoCould you please stop posting unsubstantive and flamewar comments? You did that quite a bit in this thread and unfortunately have been doing it elsewhere too. It's not what this site is for, and destroys what it is for. If you wouldn't mind reviewing https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html and taking the intended spirit of the site more to heart, we'd be grateful.
- Name_Chawps 4y agoI think you might find this article relevant: https://www.lesswrong.com/posts/fFY2HeC9i2Tx8FEnK/luck-based-medicine-my-resentful-story-of-becoming-a-medical https://www.lesswrong.com/posts/fFY2HeC9i2Tx8FEnK/luck-based...
- Trasmatta 4y agoFixing psychological issues with supplementation can sometimes be like trying to apply a bandage to a cut on your nose while somebody repeatedly punches you in the face. You should apply the bandage, but it's not going to do much good until you stop getting hit in the face.
- bitL 4y agoAlternate take: get your energy levels and body function in order first and then face whatever problem you have.
- majkinetor 4y agoSupplementation can also work wonders. There is literray almost zero downside to it except wasting money. So if you have some money to waste, start experimenting. The above advice is solid, but I would add number of others. CoQ10, C in multiple forms, ALCAR, D, Bromelain, concentrated fish oil, etc.
- nuancebydefault 4y agoPersonally i'm convinced they work. If and only if you believe in the working of supplements. I am also convinced they do not work for me, because of the premises.
- majkinetor 4y agoWhat is amazing is you dismissing the entire domain of the science with a single unsubstantiated sentence. Feel free to read some schoolar journals and research papers, rather then popular zines, if that is not too much trouble... If you could fight deficiency with a mind, we would not have deficiency disesases.
- nuancebydefault 4y agoI'm only speaking from experience. > If you could fight deficiency with a mind, we would not have deficiency disesases. That is so true. The thing is, a lot of diseases get treated as a deficiency disease.
- majkinetor 4y agoExperience is highly overrated. Some stuff may work for you some not, depending on your current state (dynamic thing, daily changing). Many stuff you can't experience but you must measure. Science is important. In accute phase response deficiency is the norm, as one example.
- bitL 4y agoVitamin B1 won a Nobel Prize in 1929 and solved a major generational illness in Japan. Lack of vitamin B3 has the same symptoms as schizophrenia (look up pellagra) and many people are misdiagnosed with it instead of tested for low brain B3 or genetic defects leading to lower absorption of B3.