SLS? It not only made orbit but also got it's payload around the moon. While it used many previously proven technologies (and it even previously flown engines

SLS? It not only made orbit but also got it's payload around the moon. While it used many previously proven technologies (and it even previously flown engines), those were either modified or combined in previously untried ways, enough that I'd call it a new vehicle for the purposes of a flight test. Speaking of previously proven technologies... the Space Shuttle made it to orbit on it's first launch attempt as well... with crew.