The whole point of an analogy is to make it easy to understand some complex idea using another simple concept. I would use instead this analogy: "alternative sp

The whole point of an analogy is to make it easy to understand some complex idea using another simple concept. I would use instead this analogy: "alternative splicing is like having a box of Legos (exons) which you can choose in different order and quantities to get different objects (proteins)." I find it more clear than "alternative splicing is like ZFS deduplication and collision detection algorithm, where blocks can be reused if they are identical". Introns are not for space saving or for efficiency. They provide variability. Is like ZFS could give you slightly different files from what you initially save. E.g. you store feral_cat.jpg spanning a number of blocks, and then just skipping blocks you can get back: feral_cat.jpg, persian_cat.jpg, egyptian_cat.jpg, russian_cat.jpg, alien_cat.jpg, tabby_cat.jpg... You never store "persian_cat.jpg" and try to save some genome space reusing blocks. persian_cat.jpg is just a possible useful image that appears magically from the original feral_cat.jpg.