4 ms·

Opiates are not neurotoxic.

• bowsamic 4y ago
  There are many reports of opiate neurotoxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Induced_Neurotoxicity.pdf https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Indu... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/
  • refurb 4y ago
    Neurotoxic in the sense of having adverse events of a neurological nature. Neurotoxic does not mean “your neurons are damaged”, at least not how those articles define it.
    • bowsamic 4y ago
      So there are two totally different definitions of neurotoxic used in the medical field?
      • refurb 4y ago
        No, the scientific field uses it differently than the layman. Neurotoxic to a scientist means “can have negative impact to neuron function, whether temporary or permanent”. The layman thinks neurotoxic means “kills your brain cells”.
        • bowsamic 4y ago
          What makes you think any of us were using the lay definition?
          • refurb 4y ago
            Because if someone said “opioids are neurotoxic” from a scientific definition, it’s stating the obvious.
        • eurasiantiger 4y ago
          Both definitions are correct. From Wikipedia: > Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant– alters the normal activity of the nervous system in such a way as to cause permanent or reversible damage to nervous tissue. Brain cells getting killed is a normal process, you could call it pruning. Cells grow back, you know!