3 ms·

Coffee and tobacco are not neurotoxic

b800h 4y ago
Sorry, that's wrong, at least as far as caffeine is concerned, and certainly as far as adverse behavioural effects ("behavioural toxicity") are concerned in humans. https://www.sciencedirect.com/science/article/pii/S1319016420300359#s0065 https://www.sciencedirect.com/science/article/pii/S131901642...
- bowsamic 4y ago
  Oh, interesting, thanks. I'm not sure why you're downvoted. What about nicotine?
  - b800h 4y ago
    No idea on that front. The caffeine one struck a chord because I'm a slow metaboliser, and it can cause me issues with anxiety under the wrong circumstances. It does make me wonder how many cases of anxiety are at least exacerbated by genetic issues with processing caffeine and other stimulants.
- lll-o-lll 4y ago
  Curse you science! Still, this is just in rats. Rats with their weak rat brains. My superior human brain can easily absorb this caffeine with no ill effects!
- prottog 4y ago
  That Kang et al. study was 50mg/kg of caffeine administered three times a day. That would be about a hundred cups a day of coffee for my body weight. Don't they say the dose makes the poison?
tsol 4y ago
Opiates are not neurotoxic.
- bowsamic 4y ago
  There are many reports of opiate neurotoxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Induced_Neurotoxicity.pdf https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Indu... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/
  - refurb 4y ago
    Neurotoxic in the sense of having adverse events of a neurological nature. Neurotoxic does not mean “your neurons are damaged”, at least not how those articles define it.
    - bowsamic 4y ago
      So there are two totally different definitions of neurotoxic used in the medical field?
      - refurb 4y ago
        No, the scientific field uses it differently than the layman. Neurotoxic to a scientist means “can have negative impact to neuron function, whether temporary or permanent”. The layman thinks neurotoxic means “kills your brain cells”.
        bowsamic 4y ago
        What makes you think any of us were using the lay definition?
        refurb 4y ago
        Because if someone said “opioids are neurotoxic” from a scientific definition, it’s stating the obvious.
        4y ago
eurasiantiger 4y ago
Both contain practically the entire family of beta-carbolines, which includes several neurotoxic alkaloids.

Sorry, that's wrong, at least as far as caffeine is concerned, and certainly as far as adverse behavioural effects ("behavioural toxicity") are concerned in humans. https://www.sciencedirect.com/science/article/pii/S1319016420300359#s0065 https://www.sciencedirect.com/science/article/pii/S131901642...

bowsamic 4y ago
Oh, interesting, thanks. I'm not sure why you're downvoted. What about nicotine?
- b800h 4y ago
  No idea on that front. The caffeine one struck a chord because I'm a slow metaboliser, and it can cause me issues with anxiety under the wrong circumstances. It does make me wonder how many cases of anxiety are at least exacerbated by genetic issues with processing caffeine and other stimulants.
lll-o-lll 4y ago
Curse you science! Still, this is just in rats. Rats with their weak rat brains. My superior human brain can easily absorb this caffeine with no ill effects!
prottog 4y ago
That Kang et al. study was 50mg/kg of caffeine administered three times a day. That would be about a hundred cups a day of coffee for my body weight. Don't they say the dose makes the poison?

tsol 4y ago

Opiates are not neurotoxic.

bowsamic 4y ago
There are many reports of opiate neurotoxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Induced_Neurotoxicity.pdf https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Indu... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/
- refurb 4y ago
  Neurotoxic in the sense of having adverse events of a neurological nature. Neurotoxic does not mean “your neurons are damaged”, at least not how those articles define it.
  - bowsamic 4y ago
    So there are two totally different definitions of neurotoxic used in the medical field?
    - refurb 4y ago
      No, the scientific field uses it differently than the layman. Neurotoxic to a scientist means “can have negative impact to neuron function, whether temporary or permanent”. The layman thinks neurotoxic means “kills your brain cells”.
      - bowsamic 4y ago
        What makes you think any of us were using the lay definition?
        refurb 4y ago
        Because if someone said “opioids are neurotoxic” from a scientific definition, it’s stating the obvious.
      - 4y ago

eurasiantiger 4y ago

Both contain practically the entire family of beta-carbolines, which includes several neurotoxic alkaloids.