4 ms·
> Opiates destroy people at the neural level. So do coffee, tobacco, antidepressants and antipsychotics.
by eurasiantiger 3y ago
> Opiates destroy people at the neural level.
So do coffee, tobacco, antidepressants and antipsychotics.
- bowsamic 3y agoCoffee and tobacco are not neurotoxic
- b800h 3y agoSorry, that's wrong, at least as far as caffeine is concerned, and certainly as far as adverse behavioural effects ("behavioural toxicity") are concerned in humans. https://www.sciencedirect.com/science/article/pii/S1319016420300359#s0065 https://www.sciencedirect.com/science/article/pii/S131901642...
- bowsamic 3y agoOh, interesting, thanks. I'm not sure why you're downvoted. What about nicotine?
- b800h 3y agoNo idea on that front. The caffeine one struck a chord because I'm a slow metaboliser, and it can cause me issues with anxiety under the wrong circumstances. It does make me wonder how many cases of anxiety are at least exacerbated by genetic issues with processing caffeine and other stimulants.
- lll-o-lll 3y agoCurse you science! Still, this is just in rats. Rats with their weak rat brains. My superior human brain can easily absorb this caffeine with no ill effects!
- prottog 3y agoThat Kang et al. study was 50mg/kg of caffeine administered three times a day. That would be about a hundred cups a day of coffee for my body weight. Don't they say the dose makes the poison?
- tsol 3y agoOpiates are not neurotoxic.
- bowsamic 3y agoThere are many reports of opiate neurotoxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949075/ https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Induced_Neurotoxicity.pdf https://www.pharmacistsmb.ca/files/2001/May-June/Opioid_Indu... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9007125/
- refurb 3y agoNeurotoxic in the sense of having adverse events of a neurological nature. Neurotoxic does not mean “your neurons are damaged”, at least not how those articles define it.
- bowsamic 3y agoSo there are two totally different definitions of neurotoxic used in the medical field?
- refurb 3y agoNo, the scientific field uses it differently than the layman. Neurotoxic to a scientist means “can have negative impact to neuron function, whether temporary or permanent”. The layman thinks neurotoxic means “kills your brain cells”.
- eurasiantiger 3y agoBoth contain practically the entire family of beta-carbolines, which includes several neurotoxic alkaloids.