2 ms·
The issue (in my view) is that the dose of efficacy to the dose of issue (when it starts causing problems) is MUCH closer for acetaminophen. Acetaminophen 'usa
by Kirby64 4y ago
The issue (in my view) is that the dose of efficacy to the dose of issue (when it starts causing problems) is MUCH closer for acetaminophen.
Acetaminophen 'usage' dose is usually 500-1000mg (1-2 pills). The dosage where it becomes significantly toxic is ~7500-10000mg (7.5-10g), which is somewhere in the range of 10x the dose.
Ibuprofen on the other hand, 'usage' dose is 200-400mg (1-2 pills, again). Toxic dosage is closer to ~16000-25000mg (16-25g), which is more like 50x the usable dose.
Since people invariably take more than the recommended dose when they're really in pain, I'd prefer the NSAID that is less toxic at higher doses... since it's not like they post toxic doses on the side of bottles.