2 ms·

Are they? Maybe acetaminophen (i.e. paracetamol) is many times more dangerous than ibuprofen, but still, in absolute terms it must be low if used according to g

Are they? Maybe acetaminophen (i.e. paracetamol) is many times more dangerous than ibuprofen, but still, in absolute terms it must be low if used according to guidelines. I mean, most people don’t know anyone who has died or been injured from acetaminophen, so from most normal people’s everyday perspective it simply does the same thing as ibuprofen, regardless of whether that’s scientifically correct. Thus it’s easy to understand why people talk about them in the same breath.

szundi 4y ago
Having a bad liver at old age. Is these issues contribute to earlier death? Can it be proven to linked to paracetamol? No. So we know nothing basically
- _2uwr 4y ago
  Having a bad liver will mean its not capable of generating enough glutathione. Paracetamol is a state licenced poison which depletes the body of glutathione. In order to replenish glutathione or help the liver recover from state licenced poisons like alcohol and paracetamol, take/increase cysteine. Some other experts will step in and say its hard to absorb from the gut so take N-Acetyl Cysteine aka NAC, but what they dont tell you about the acetyl part is it stimulates immune cells which then cause their own problems namely inflammation. Acetic Acid which is the Acetyl part of NAC lowers the GI of food, which is why adding vinegar to food is useful at reducing the blood sugar spike and used to be used in some diabetic conditions. The immune cells attack the sugars except starch. Ironically the liver also needs glucose to make glutathione, so what I havent established is this. Do we feed off our own immune cells or do we simply excrete them through the usual methods or a bit of both? If we are not catabolising and feeding off the immune cells which have attacked the food we have eaten, is our immune system helping us to stay slim and healthy? On the subject of aspirin being a COX inhibitor, so are Omega 3's. Omega 3's interact with the COX enzyme's so their Nett Effect is tantamount to being a COX inhibitor! Omega-3's also reduce inflammation but they take several weeks to months to have a noticable effect, in which time, weather can improve which is cited as the cause of the improvements. Short term once or twice use cases, Aspirin can be useful, but if anyone is needing to consume anti inflammatories like Aspirin, consider looking into dietary changes which can also reduce inflammation, like increasing Omega-3 intake. On the point of the indoleamine dioxygenase, there are many enzymes which can target cancer, copper will increase some of the InterLeukins which modulate the immune response. It is handy to know that aspirin slows the breakdown of the amino acid tryptophan into its metabolite kynurenine by inhibiting associated enzymes called indoleamine dioxygenases, or IDOs. I'll have to try taking some aspirin with some tryptophan on an empty stomach or protein free meal so that the tryptophan is not crowded out by the handful of amino acids typically found in meat and other protein sources at the blood brain barrier, in order to see if it will improve my mood. Blue light exposure via the eyes is needed to increase the serotonin in the brain according to some studies.
Kirby64 4y ago
The issue (in my view) is that the dose of efficacy to the dose of issue (when it starts causing problems) is MUCH closer for acetaminophen. Acetaminophen 'usage' dose is usually 500-1000mg (1-2 pills). The dosage where it becomes significantly toxic is ~7500-10000mg (7.5-10g), which is somewhere in the range of 10x the dose. Ibuprofen on the other hand, 'usage' dose is 200-400mg (1-2 pills, again). Toxic dosage is closer to ~16000-25000mg (16-25g), which is more like 50x the usable dose. Since people invariably take more than the recommended dose when they're really in pain, I'd prefer the NSAID that is less toxic at higher doses... since it's not like they post toxic doses on the side of bottles.

szundi 4y ago

Having a bad liver at old age. Is these issues contribute to earlier death? Can it be proven to linked to paracetamol? No. So we know nothing basically

_2uwr 4y ago
Having a bad liver will mean its not capable of generating enough glutathione. Paracetamol is a state licenced poison which depletes the body of glutathione. In order to replenish glutathione or help the liver recover from state licenced poisons like alcohol and paracetamol, take/increase cysteine. Some other experts will step in and say its hard to absorb from the gut so take N-Acetyl Cysteine aka NAC, but what they dont tell you about the acetyl part is it stimulates immune cells which then cause their own problems namely inflammation. Acetic Acid which is the Acetyl part of NAC lowers the GI of food, which is why adding vinegar to food is useful at reducing the blood sugar spike and used to be used in some diabetic conditions. The immune cells attack the sugars except starch. Ironically the liver also needs glucose to make glutathione, so what I havent established is this. Do we feed off our own immune cells or do we simply excrete them through the usual methods or a bit of both? If we are not catabolising and feeding off the immune cells which have attacked the food we have eaten, is our immune system helping us to stay slim and healthy? On the subject of aspirin being a COX inhibitor, so are Omega 3's. Omega 3's interact with the COX enzyme's so their Nett Effect is tantamount to being a COX inhibitor! Omega-3's also reduce inflammation but they take several weeks to months to have a noticable effect, in which time, weather can improve which is cited as the cause of the improvements. Short term once or twice use cases, Aspirin can be useful, but if anyone is needing to consume anti inflammatories like Aspirin, consider looking into dietary changes which can also reduce inflammation, like increasing Omega-3 intake. On the point of the indoleamine dioxygenase, there are many enzymes which can target cancer, copper will increase some of the InterLeukins which modulate the immune response. It is handy to know that aspirin slows the breakdown of the amino acid tryptophan into its metabolite kynurenine by inhibiting associated enzymes called indoleamine dioxygenases, or IDOs. I'll have to try taking some aspirin with some tryptophan on an empty stomach or protein free meal so that the tryptophan is not crowded out by the handful of amino acids typically found in meat and other protein sources at the blood brain barrier, in order to see if it will improve my mood. Blue light exposure via the eyes is needed to increase the serotonin in the brain according to some studies.

Kirby64 4y ago

The issue (in my view) is that the dose of efficacy to the dose of issue (when it starts causing problems) is MUCH closer for acetaminophen. Acetaminophen 'usage' dose is usually 500-1000mg (1-2 pills). The dosage where it becomes significantly toxic is ~7500-10000mg (7.5-10g), which is somewhere in the range of 10x the dose. Ibuprofen on the other hand, 'usage' dose is 200-400mg (1-2 pills, again). Toxic dosage is closer to ~16000-25000mg (16-25g), which is more like 50x the usable dose. Since people invariably take more than the recommended dose when they're really in pain, I'd prefer the NSAID that is less toxic at higher doses... since it's not like they post toxic doses on the side of bottles.