7 ms·

I've always though Aspirin was a deprecated drug but lately I've heard reports from people who claim it's the only thing that helps their arthritis or other iss

I've always though Aspirin was a deprecated drug but lately I've heard reports from people who claim it's the only thing that helps their arthritis or other issues. Maybe there is something behind it.

readthenotes1 4y ago
deprecated for children. works well for people with atherosclerosis. ibuprofen and acetominophen are hardly safe...
- astrange 4y ago
  They are very safe when taken as prescribed but quite dangerous when you don't read the directions. Although IIRC taking fever reducers when sick significantly increases how long it takes to recover. Those fevers are there for a reason.
  - unlikelymordant 4y ago
    I guess theres always a caveat, but fevers can get too high and go for too long, in which case reducing the fever might be a good idea. But if it gets to that point, you should be working with a doctor to make those decisions.
    - dham 4y ago
      This is a misnomer though. Your body will not make the fever too high in the case of fighting a virus, so danger is low. From an evolutionary standpoint this would make no sense. For a bacterial infection I think the chance of going to the danger zone is higher though. Typically it's better to just let the fever ride when you have a virus, unless it's making you you so uncomfortable you can't rest/sleep.
      - readthenotes1 4y ago
        Well, brain damage may not be a detriment to some. Btw, "misnomer" doesn't mean what you think it means.
  - cortesoft 4y ago
    The problem with acetaminophen is that the dangerous dose is not much higher than the recommended dose for a subset of the population. There are people who can die if they only take a few extra... and since it has a reputation as a safe drug, people don't think twice about taking extra.
    - Arn_Thor 4y ago
      This is so strange to me. I would never in a million years go beyond the recommended dosage without consulting a doctor. But I now realize that's just me, and if we can offer safer drugs that won't be as harmful if people exceed the dosage, so much the better.
  - School-Cotton 4y ago
    > taking fever reducers when sick significantly increases how long it takes to recover I’ve also heard this, and always wondered whether it was true or a myth. I really have no idea. Any chance you have a reputable source?
    - callahad 4y ago
      Searching for "antipyretic prolong pubmed" turns up some good trailheads. Seems like consensus is that fever is likely beneficial and routine suppression is probably not supported by evidence. There's conflicting data on whether suppressing fever delays recovery. A few jumping off points: https://pubmed.ncbi.nlm.nih.gov/23664629/ https://pubmed.ncbi.nlm.nih.gov/23664629/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703655/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703655/ https://pubmed.ncbi.nlm.nih.gov/20920066/ https://pubmed.ncbi.nlm.nih.gov/20920066/ https://pubmed.ncbi.nlm.nih.gov/11130213/ https://pubmed.ncbi.nlm.nih.gov/11130213/
    - intelVISA 4y ago
      Would you turn off your CPU fan when it spins to 100% from opening ${electron app} just because the sound was annoying?
      - mrguyorama 4y ago
        Suppressing the fever is more like significantly undervolting your CPU because the heat output of your gaming computer makes your room uncomfortably warm. Sure your room isn't too hot anymore, but the CPU needed that power to do useful work, and it's possible it won't be able to keep up with what you need anymore.
coldtea 4y ago
Aspirin deprecated? It's one of the most useful and most widespread in use drug on the planet - for far more than "arthritis". It's the WD-40 of drugs. Ah, it's even in TFA: "Aspirin, which is a nonsteroidal anti-inflammatory drug, is one of the most widely used medications in the world. It is used to treat pain, fever and inflammation, and an estimated 29 million people in the U.S. take it daily to reduce the risk of cardiovascular diseases."
- graderjs 4y ago
  I love to see some info like this and want to share my experiences. I'm a fan of small-molecule, well-tolerated, out-of-patent (cheap), widely available pharms like this in the class of "maintenance" and "enhancement" rather than "acute therapy" (although there is cross-over: i.e, have an acute headache? aspirin helps). Some things in my list right now: acetylcysteine, aspirin, metformin Besides aspirin, I don't take these regularly. And these days I take aspirin less and less, because I found I don't need it any more and I built up a healthy routine anyway. In general I think eating right (lots of vegetables), good microbiome, plant medicine (for example turmeric (with milk and black pepper) black seed / nigella sativa as seeds or oil), and exercise are better than pharmaceuticals for general enhancement and maintenance of health--but there are some really good pharmaceuticals. Everyone's body is different to some extent tho, and bodies change over time (for eg, gene expression changes over time), so what works for you might change over time. This isn't medical advice, consult your doc, but here's other things I think a worth a shot (worked for me in the past) in limited doses: piracetam - for building new brain cells, and increasing oxygen and decreasing blood viscosity pentoxifylline - for de-aging your vascular system fexofenadine - great for me for pollen allergies, and generalized severe inflammation (ie, say you had a really stressful thing) doxycycline - good antibiotic in small dose but can have some weird side effects in some people, or if taken for long time, but strangely it also help with tissue repair. fluorometholone - great in eye drop for itchy eyes, also instantly reduces brain inflammation / headache, and chills you out--for me at least--after dropping a couple drops in each eye--but use sparingly as it's a strong corticosteroid so you don't want to dampen the immune system in your sinuses etc as that will lead to infection! In general I have the view that all pharams and most plant medicines are "toxins" (on some level, at some dose obviously, but in general too) in the sense that there's very few things which are just uniformly healthy in the class of drugs--yet nevertheless there are some wonder drugs like these that I think can be really enhancing to health if used right. After a couple years taking aspirin at low dose regularly, I started noticing I no longer needed it. That coincided with me adopting a regular meditation/energy work/ some yoga practice. Currently on my to-try list is: ashwagandha Please exercise caution in your exploring -- some of what works for me might even be dangerous for you--everyone is different!! :) ;p xx ;p
vlovich123 4y ago
Are you perhaps thinking Tylenol?
- deleted 4y ago
  [deleted]
01100011 4y ago
For a while it was recommended that older folks take a daily baby aspirin to lower their risk of ischemic heart attacks and strokes due to aspirin's function as a mild blood thinner. Large studies have shown the increased risk of hemorrhagic stroke offsets the benefits to ischemia and now taking a daily baby aspirin is not recommended except in certain cases. Aspirin still has many uses and long term use is associated with other positive outcomes, like lower cancer risk.
cperciva 4y ago
I know a lot of doctors recommend ibuprofen over aspirin because ibuprofen is perceived to be a safer NSAID. I'm not sure if it's actually safer in adults or only in children though.
- tacroqueen 4y ago
  GI side effects in general and bleeding in particular are higher in analgesic dose level of aspirin. Aspirin is a very blunt instrument - it is both anti-inflammatory and anti-thrombotic - it destroys your platelet function even in low doses - this can be a feature/benefit (ie stroke and coronary artery disease or MI) - but for pure analgesia it usually just means increasing bleeding risk for no benefit.
  - bigDinosaur 4y ago
    I don't believe this is a meaningful risk for a healthy person just taking a few aspirin. Certainly you don't want to consume too much (like all medicines) nor use it chronically (unless the alternative risks are worse).
heavyset_go 4y ago
As far as I know, aspirin is the one NSAID that doesn't potentially raise risks of heart attacks or strokes. Other drugs also can be hard on the liver and kidneys.
- masklinn 4y ago
  TBF it literally does the opposite, even in countries which have (culturally?) switched away from aspirin as an analgesic, it’s still in use as a blood thinner for stroke prevention and management.
hoseja 4y ago
It only seems that way because it's dirt cheap and pharma can't profit off of it very much.
wombatpm 4y ago
Aspirin and other NSAID were supposed to go the way of the dinosaurs. COX2 inhibitors we’re supposed to be the golden child. Too bad it caused kidney and liver damage

readthenotes1 4y ago

deprecated for children. works well for people with atherosclerosis. ibuprofen and acetominophen are hardly safe...

astrange 4y ago
They are very safe when taken as prescribed but quite dangerous when you don't read the directions. Although IIRC taking fever reducers when sick significantly increases how long it takes to recover. Those fevers are there for a reason.
- unlikelymordant 4y ago
  I guess theres always a caveat, but fevers can get too high and go for too long, in which case reducing the fever might be a good idea. But if it gets to that point, you should be working with a doctor to make those decisions.
  - dham 4y ago
    This is a misnomer though. Your body will not make the fever too high in the case of fighting a virus, so danger is low. From an evolutionary standpoint this would make no sense. For a bacterial infection I think the chance of going to the danger zone is higher though. Typically it's better to just let the fever ride when you have a virus, unless it's making you you so uncomfortable you can't rest/sleep.
    - readthenotes1 4y ago
      Well, brain damage may not be a detriment to some. Btw, "misnomer" doesn't mean what you think it means.
- cortesoft 4y ago
  The problem with acetaminophen is that the dangerous dose is not much higher than the recommended dose for a subset of the population. There are people who can die if they only take a few extra... and since it has a reputation as a safe drug, people don't think twice about taking extra.
  - Arn_Thor 4y ago
    This is so strange to me. I would never in a million years go beyond the recommended dosage without consulting a doctor. But I now realize that's just me, and if we can offer safer drugs that won't be as harmful if people exceed the dosage, so much the better.
- School-Cotton 4y ago
  > taking fever reducers when sick significantly increases how long it takes to recover I’ve also heard this, and always wondered whether it was true or a myth. I really have no idea. Any chance you have a reputable source?
  - callahad 4y ago
    Searching for "antipyretic prolong pubmed" turns up some good trailheads. Seems like consensus is that fever is likely beneficial and routine suppression is probably not supported by evidence. There's conflicting data on whether suppressing fever delays recovery. A few jumping off points: https://pubmed.ncbi.nlm.nih.gov/23664629/ https://pubmed.ncbi.nlm.nih.gov/23664629/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703655/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703655/ https://pubmed.ncbi.nlm.nih.gov/20920066/ https://pubmed.ncbi.nlm.nih.gov/20920066/ https://pubmed.ncbi.nlm.nih.gov/11130213/ https://pubmed.ncbi.nlm.nih.gov/11130213/
  - intelVISA 4y ago
    Would you turn off your CPU fan when it spins to 100% from opening ${electron app} just because the sound was annoying?
    - mrguyorama 4y ago
      Suppressing the fever is more like significantly undervolting your CPU because the heat output of your gaming computer makes your room uncomfortably warm. Sure your room isn't too hot anymore, but the CPU needed that power to do useful work, and it's possible it won't be able to keep up with what you need anymore.

coldtea 4y ago

Aspirin deprecated? It's one of the most useful and most widespread in use drug on the planet - for far more than "arthritis". It's the WD-40 of drugs. Ah, it's even in TFA: "Aspirin, which is a nonsteroidal anti-inflammatory drug, is one of the most widely used medications in the world. It is used to treat pain, fever and inflammation, and an estimated 29 million people in the U.S. take it daily to reduce the risk of cardiovascular diseases."

graderjs 4y ago
I love to see some info like this and want to share my experiences. I'm a fan of small-molecule, well-tolerated, out-of-patent (cheap), widely available pharms like this in the class of "maintenance" and "enhancement" rather than "acute therapy" (although there is cross-over: i.e, have an acute headache? aspirin helps). Some things in my list right now: acetylcysteine, aspirin, metformin Besides aspirin, I don't take these regularly. And these days I take aspirin less and less, because I found I don't need it any more and I built up a healthy routine anyway. In general I think eating right (lots of vegetables), good microbiome, plant medicine (for example turmeric (with milk and black pepper) black seed / nigella sativa as seeds or oil), and exercise are better than pharmaceuticals for general enhancement and maintenance of health--but there are some really good pharmaceuticals. Everyone's body is different to some extent tho, and bodies change over time (for eg, gene expression changes over time), so what works for you might change over time. This isn't medical advice, consult your doc, but here's other things I think a worth a shot (worked for me in the past) in limited doses: piracetam - for building new brain cells, and increasing oxygen and decreasing blood viscosity pentoxifylline - for de-aging your vascular system fexofenadine - great for me for pollen allergies, and generalized severe inflammation (ie, say you had a really stressful thing) doxycycline - good antibiotic in small dose but can have some weird side effects in some people, or if taken for long time, but strangely it also help with tissue repair. fluorometholone - great in eye drop for itchy eyes, also instantly reduces brain inflammation / headache, and chills you out--for me at least--after dropping a couple drops in each eye--but use sparingly as it's a strong corticosteroid so you don't want to dampen the immune system in your sinuses etc as that will lead to infection! In general I have the view that all pharams and most plant medicines are "toxins" (on some level, at some dose obviously, but in general too) in the sense that there's very few things which are just uniformly healthy in the class of drugs--yet nevertheless there are some wonder drugs like these that I think can be really enhancing to health if used right. After a couple years taking aspirin at low dose regularly, I started noticing I no longer needed it. That coincided with me adopting a regular meditation/energy work/ some yoga practice. Currently on my to-try list is: ashwagandha Please exercise caution in your exploring -- some of what works for me might even be dangerous for you--everyone is different!! :) ;p xx ;p

vlovich123 4y ago

Are you perhaps thinking Tylenol?

deleted 4y ago
[deleted]

01100011 4y ago

For a while it was recommended that older folks take a daily baby aspirin to lower their risk of ischemic heart attacks and strokes due to aspirin's function as a mild blood thinner. Large studies have shown the increased risk of hemorrhagic stroke offsets the benefits to ischemia and now taking a daily baby aspirin is not recommended except in certain cases. Aspirin still has many uses and long term use is associated with other positive outcomes, like lower cancer risk.

cperciva 4y ago

I know a lot of doctors recommend ibuprofen over aspirin because ibuprofen is perceived to be a safer NSAID. I'm not sure if it's actually safer in adults or only in children though.

tacroqueen 4y ago
GI side effects in general and bleeding in particular are higher in analgesic dose level of aspirin. Aspirin is a very blunt instrument - it is both anti-inflammatory and anti-thrombotic - it destroys your platelet function even in low doses - this can be a feature/benefit (ie stroke and coronary artery disease or MI) - but for pure analgesia it usually just means increasing bleeding risk for no benefit.
- bigDinosaur 4y ago
  I don't believe this is a meaningful risk for a healthy person just taking a few aspirin. Certainly you don't want to consume too much (like all medicines) nor use it chronically (unless the alternative risks are worse).

heavyset_go 4y ago

As far as I know, aspirin is the one NSAID that doesn't potentially raise risks of heart attacks or strokes. Other drugs also can be hard on the liver and kidneys.

masklinn 4y ago
TBF it literally does the opposite, even in countries which have (culturally?) switched away from aspirin as an analgesic, it’s still in use as a blood thinner for stroke prevention and management.

hoseja 4y ago

It only seems that way because it's dirt cheap and pharma can't profit off of it very much.

wombatpm 4y ago

Aspirin and other NSAID were supposed to go the way of the dinosaurs. COX2 inhibitors we’re supposed to be the golden child. Too bad it caused kidney and liver damage