There was a discovery that acetaminophen plus ibuprofen produce a synergistic effect similar to opioids. [0] This combination stresses the liver, stomach lining

There was a discovery that acetaminophen plus ibuprofen produce a synergistic effect similar to opioids. [0] This combination stresses the liver, stomach lining (without famotidine), and kidneys so it's not something to use chronically. It was even OTC productized as "Advil Dual Action". [1] 0. https://pubmed.ncbi.nlm.nih.gov/20142348/ https://pubmed.ncbi.nlm.nih.gov/20142348/ 1. https://www.ada.org/publications/ada-news/2020/march/fda-approves-combination-ibuprofen-acetaminophen-drug-for-us https://www.ada.org/publications/ada-news/2020/march/fda-app...