It's worth noting that Wireguard doesn't use any persistent connection (although you can configure clients to send Keepalive packets). It sends UDP packets only

It's worth noting that Wireguard doesn't use any persistent connection (although you can configure clients to send Keepalive packets). It sends UDP packets only as long as you're opening connections to remote endpoints over its network interface, and lazily sends handshakes only when it determines it hasn't sent one in a while. In the normal setup, that network interface is "persistent," but only in the sense it has an entry in the routing table, etc.; by default there is no daemon sending any packets over it (unlike say, OpenVPN for example), because the nature of UDP means there is no connection to maintain.