4 ms·

Except those doses might not be right if you're consuming certain things that interact with those drugs that seem innocuous. Like Grapefruit, for example. If yo

Except those doses might not be right if you're consuming certain things that interact with those drugs that seem innocuous. Like Grapefruit, for example. If you consume grapefruit and take acetaminophen, more of the drug will get into your bloodstream than expected, and prescriptions doses won't take that into account. You have to be careful taking a lot of drugs if you eat grapefruit, btw, for this reason, not just acetaminophen. "White grapefruit juice increased concentrations of acetaminophen in mice both 1 hour and 2 hours after feeding compared to controls. In contrast, pink grapefruit juice increased acetaminophen concentrations 2 hours after feeding compared to controls."[1] [1]: https://pubmed.ncbi.nlm.nih.gov/19053875/ https://pubmed.ncbi.nlm.nih.gov/19053875/

News-Dog 4y ago
'P450 Drug Interactions' Cytochrome P450 : https://en.wikipedia.org/wiki/P450 https://en.wikipedia.org/wiki/P450 Edit - Add; List of Cytochrome P450 Modulators : https://en.wikipedia.org/wiki/List_of_cytochrome_P450_modulators https://en.wikipedia.org/wiki/List_of_cytochrome_P450_modula... 'Acetaminophen and Alcohol Hepatotoxicity, Liver damage' <https://scholar.google.com/scholar?&q='Acetaminophen and Alcohol Hepatotoxicity, Liver damage' https://scholar.google.com/scholar?&q='Acetaminophen and Alc...> N-acetyl-para-aminophenol (APAP), Acetaminophen, Tylenol, Paracetamol, Panadol, others : https://en.wikipedia.org/wiki/Acetaminophen https://en.wikipedia.org/wiki/Acetaminophen
mrangle 4y ago
Blood concentrations rise because grapefruit slows liver processing. That's not the same as grapefruit increasing the risk of acetaminophen liver damage, which is the OD concern. I'm not saying it doesn't, but I've never read that warning and I've been taking it for fifteen years. You'd want to show the research that states that grapefruit increases acetaminophen toxicity. They even sell extended release acetaminophen, which prolongs liver processing. Though, I'm not a fan because I think it is rougher on the liver. But health damaging risk is another issue.

News-Dog 4y ago

'P450 Drug Interactions' Cytochrome P450 : https://en.wikipedia.org/wiki/P450 https://en.wikipedia.org/wiki/P450 Edit - Add; List of Cytochrome P450 Modulators : https://en.wikipedia.org/wiki/List_of_cytochrome_P450_modulators https://en.wikipedia.org/wiki/List_of_cytochrome_P450_modula... 'Acetaminophen and Alcohol Hepatotoxicity, Liver damage' <https://scholar.google.com/scholar?&q='Acetaminophen and Alcohol Hepatotoxicity, Liver damage' https://scholar.google.com/scholar?&q='Acetaminophen and Alc...> N-acetyl-para-aminophenol (APAP), Acetaminophen, Tylenol, Paracetamol, Panadol, others : https://en.wikipedia.org/wiki/Acetaminophen https://en.wikipedia.org/wiki/Acetaminophen

mrangle 4y ago

Blood concentrations rise because grapefruit slows liver processing. That's not the same as grapefruit increasing the risk of acetaminophen liver damage, which is the OD concern. I'm not saying it doesn't, but I've never read that warning and I've been taking it for fifteen years. You'd want to show the research that states that grapefruit increases acetaminophen toxicity. They even sell extended release acetaminophen, which prolongs liver processing. Though, I'm not a fan because I think it is rougher on the liver. But health damaging risk is another issue.