5 ms·

It is also an NSAID. You mean “other NSAIDs”.

by epgui 4y ago

dragonwriter 4y ago
> It is also an NSAID. No, its not. Acetaminophen is not an NSAID (which is why NSAIDs are better on inflammatory pain.)
- hilbert42 4y ago
  Techically, you're right but it's often grouped with them. I like to view it living in no-man's-land as a cast off from NSAIDs as its chemical origins are so similar to the former. Little wonder the confusion. I'd add that confusion is only compounded when it's mixed with NSAIDs such aspirin and ibuprofen. Such mixtures are pretty popular.
  - News-Dog 4y ago
    Non-Steroidal Anti-Inflammatory Drugs (NSAID) : https://en.wikipedia.org/wiki/NSAIDs https://en.wikipedia.org/wiki/NSAIDs Edit - Add; 'NSAIDs and Gastrointestinal (GI) Injury' <https://scholar.google.com/scholar?&q='NSAIDs and Gastrointestinal (GI) Injury' https://scholar.google.com/scholar?&q='NSAIDs and Gastrointe...>
  - dragonwriter 4y ago
    > Techically, you’re right but it’s often grouped with them. It is usually distinguished from them, especially as the one OTC painkiller typically usable by people with conditions for which they should not take NSAIDs, and which lacks the issues with long-term use of NSAIDs. OTOH, with more digging, while most medical sources distinguish it, it is occasionally identified as an NSAID in the literature – ironically, the first source I could find that does that is a paper which both calls it one and contrasts it with NSAIDs, so it seems a bit confused – and it apparently has some (though weak enough compared to the things usually labelled NSAIDs that most sources just straight up refer to it as not being anti-inflammatory) anti-inflammatory effect.
    - epgui 4y ago
      Another entire class of compounds that are not usually called "NSAID" but that you could arguably call that, are 5-ASA/mesalazine and many of its related compounds. Although I think this would be more controversial than the inclusion of paracetamol. Personally, I think many DMARDs might be considered NSAIDs as well (except by somewhat arbitrary-seeming exclusion). When I really think about it, I think the nomenclature might just be conventional and not necessarily make much sense.
- epgui 4y ago
  I'm a biochemist and I find the distinction arbitrary. Paracetamol/acetaminophen is anti-inflammatory, and it is non-steroidal. That to me is enough to warrant inclusion in the category "NSAID". It doesn't mean it has the same mechanism of action, the same COX selectivity, the same side effect profile, etc, as all other drugs within the class.

It is also an NSAID. You mean “other NSAIDs”.

by epgui 4y ago

It is also an NSAID. You mean “other NSAIDs”.

> It is also an NSAID. No, its not. Acetaminophen is not an NSAID (which is why NSAIDs are better on inflammatory pain.)

hilbert42 4y ago
Techically, you're right but it's often grouped with them. I like to view it living in no-man's-land as a cast off from NSAIDs as its chemical origins are so similar to the former. Little wonder the confusion. I'd add that confusion is only compounded when it's mixed with NSAIDs such aspirin and ibuprofen. Such mixtures are pretty popular.
- News-Dog 4y ago
  Non-Steroidal Anti-Inflammatory Drugs (NSAID) : https://en.wikipedia.org/wiki/NSAIDs https://en.wikipedia.org/wiki/NSAIDs Edit - Add; 'NSAIDs and Gastrointestinal (GI) Injury' <https://scholar.google.com/scholar?&q='NSAIDs and Gastrointestinal (GI) Injury' https://scholar.google.com/scholar?&q='NSAIDs and Gastrointe...>
- dragonwriter 4y ago
  > Techically, you’re right but it’s often grouped with them. It is usually distinguished from them, especially as the one OTC painkiller typically usable by people with conditions for which they should not take NSAIDs, and which lacks the issues with long-term use of NSAIDs. OTOH, with more digging, while most medical sources distinguish it, it is occasionally identified as an NSAID in the literature – ironically, the first source I could find that does that is a paper which both calls it one and contrasts it with NSAIDs, so it seems a bit confused – and it apparently has some (though weak enough compared to the things usually labelled NSAIDs that most sources just straight up refer to it as not being anti-inflammatory) anti-inflammatory effect.
  - epgui 4y ago
    Another entire class of compounds that are not usually called "NSAID" but that you could arguably call that, are 5-ASA/mesalazine and many of its related compounds. Although I think this would be more controversial than the inclusion of paracetamol. Personally, I think many DMARDs might be considered NSAIDs as well (except by somewhat arbitrary-seeming exclusion). When I really think about it, I think the nomenclature might just be conventional and not necessarily make much sense.
epgui 4y ago
I'm a biochemist and I find the distinction arbitrary. Paracetamol/acetaminophen is anti-inflammatory, and it is non-steroidal. That to me is enough to warrant inclusion in the category "NSAID". It doesn't mean it has the same mechanism of action, the same COX selectivity, the same side effect profile, etc, as all other drugs within the class.