5 ms·

It sure is. I’ve heard it argued that Tylenol would never be approved by the FDA were it introduced as a new medication. Even if it were it would be pulled fr

It sure is. I’ve heard it argued that Tylenol would never be approved by the FDA were it introduced as a new medication. Even if it were it would be pulled from the market after the first few waves of overdoses. Really doesn’t help that it’s hidden in a bunch of medications and doesn’t mix with liquor. Quite safe when taken as prescribed or directed though.

refurb 4y ago
It's kind of silly to say "the FDA would never approved it today". The FDA pulls drugs off the market all the time. https://www.federalregister.gov/documents/2018/12/11/2018-26712/list-of-drug-products-that-have-been-withdrawn-or-removed-from-the-market-for-reasons-of-safety-or https://www.federalregister.gov/documents/2018/12/11/2018-26... Approximately 150 people die in the US each year due to accidental overdoses of acetaminophen. At the peak, 16,500 people died in the US from NSAIDs (aspirin, ibuprofen, etc) each year, mostly from GI bleeds. Acetaminophen looks massively safer than the other alternatives right now.
- hilbert42 4y ago
  Yes, but it's not as effective as many of those other drugs. That's a significant part of the problem.
  - refurb 4y ago
    What do mean "not as effective"? For what? And I'm not sure what your point is. Acetaminophen is very effective for lots of pain. And it doesn't kill as many people.
hilbert42 4y ago
"I’ve heard it argued that Tylenol would never be approved by the FDA were it introduced as a new medication." You're likely right on the grounds that it's not a particularly good painkiller—my own experience is that it's marginally better than nothing (which is also pretty much the official position)—and on its now well defined dangers. The combined assessments would likely be insufficient for approval.
- prirun 4y ago
  I got sick Friday (turned out to be Covid - 1st time for me I know of), had a terrible headache all day, still had it Saturday morning, so took one 500mg (extra strength) acetaminophen. It knocked out the headache very quickly and it hasn't come back. So in my case, it was way better than nothing and I wish I had taken it the day before instead of suffering with a heading for over 24 hours. I for one am glad it's around.
  - hilbert42 4y ago
    You are very lucky, 1000mg (two tablets) has absolutely no effect on my headaches. As for toothaches, I may as well suck M&M's—unlike acetaminophen, they at least taste sweet. Unfortunately, that's how it goes for many people. BTW, where I live, all OTC acetaminophen tablets are 500mg (and often come in packets of 100 tablets), and the usual recommended single dose is 1000mg (max 4000mg daily). __ Edit: https://thenewdaily.com.au/life/wellbeing/2021/04/05/paracetamol-effective-questions/ https://thenewdaily.com.au/life/wellbeing/2021/04/05/paracet....

refurb 4y ago

It's kind of silly to say "the FDA would never approved it today". The FDA pulls drugs off the market all the time. https://www.federalregister.gov/documents/2018/12/11/2018-26712/list-of-drug-products-that-have-been-withdrawn-or-removed-from-the-market-for-reasons-of-safety-or https://www.federalregister.gov/documents/2018/12/11/2018-26... Approximately 150 people die in the US each year due to accidental overdoses of acetaminophen. At the peak, 16,500 people died in the US from NSAIDs (aspirin, ibuprofen, etc) each year, mostly from GI bleeds. Acetaminophen looks massively safer than the other alternatives right now.

hilbert42 4y ago
Yes, but it's not as effective as many of those other drugs. That's a significant part of the problem.
- refurb 4y ago
  What do mean "not as effective"? For what? And I'm not sure what your point is. Acetaminophen is very effective for lots of pain. And it doesn't kill as many people.

hilbert42 4y ago

"I’ve heard it argued that Tylenol would never be approved by the FDA were it introduced as a new medication." You're likely right on the grounds that it's not a particularly good painkiller—my own experience is that it's marginally better than nothing (which is also pretty much the official position)—and on its now well defined dangers. The combined assessments would likely be insufficient for approval.

prirun 4y ago
I got sick Friday (turned out to be Covid - 1st time for me I know of), had a terrible headache all day, still had it Saturday morning, so took one 500mg (extra strength) acetaminophen. It knocked out the headache very quickly and it hasn't come back. So in my case, it was way better than nothing and I wish I had taken it the day before instead of suffering with a heading for over 24 hours. I for one am glad it's around.
- hilbert42 4y ago
  You are very lucky, 1000mg (two tablets) has absolutely no effect on my headaches. As for toothaches, I may as well suck M&M's—unlike acetaminophen, they at least taste sweet. Unfortunately, that's how it goes for many people. BTW, where I live, all OTC acetaminophen tablets are 500mg (and often come in packets of 100 tablets), and the usual recommended single dose is 1000mg (max 4000mg daily). __ Edit: https://thenewdaily.com.au/life/wellbeing/2021/04/05/paracetamol-effective-questions/ https://thenewdaily.com.au/life/wellbeing/2021/04/05/paracet....