One big difference is that spacecraft crews actually train on their craft, just like aircraft pilots, and extensively. So they know what all the controls are f

One big difference is that spacecraft crews actually train on their craft, just like aircraft pilots, and extensively. So they know what all the controls are for, what they do, what to do in an emergency, etc. When a pilot wants to fly a different model of airplane, they have to be retrained (or cross-trained rather) on that model, since the controls and procedures may be different. For some strange reason, people expect to just jump in the driver's seat of a car and drive away with zero training.