You probably could, but I’d recommend getting a chip with a dedicated I2S peripheral and use freertos with a high priority dedicated audio task that’s sole task

You probably could, but I’d recommend getting a chip with a dedicated I2S peripheral and use freertos with a high priority dedicated audio task that’s sole task is processing audio. You really don’t want to miss an audio sample. It’s very audible, and depending on what you’re doing makes audio processing essentially a hard real-time constraint.