The Plague of Justinian (the first major instance of the disease) in the 6th Century wiped out at least 40% of the population of Constantinople--the largest and

The Plague of Justinian (the first major instance of the disease) in the 6th Century wiped out at least 40% of the population of Constantinople--the largest and most advanced city in Europe at the time. It's estimated it wiped out 25-60% of the population of Europe over the course of 2 centuries (15-100 million people). https://en.wikipedia.org/wiki/Plague_of_Justinian https://en.wikipedia.org/wiki/Plague_of_Justinian