I'd still use AES256 or ChaCha20 (as part of a secure AEAD construction if at all possible) for any new crypto system designs, or a new profile of an existing s

I'd still use AES256 or ChaCha20 (as part of a secure AEAD construction if at all possible) for any new crypto system designs, or a new profile of an existing system. See "Understanding brute force" by Daniel J. Bernstein. Get someone who knows what they are doing to look at the basic design before you start.