Just spitballing and I have no particular expertise. I do not have experience with Ayahausca, but I do have experience with Psylocibin, LSD, Ketamine, Salvia D

Just spitballing and I have no particular expertise. I do not have experience with Ayahausca, but I do have experience with Psylocibin, LSD, Ketamine, Salvia Divinorum, and a few other things. Psychedelics disrupt the Default Mode Network (this has been shown in brain imaging studies), which the brain process which covers internally directed thought, self-reflection, self-criticism, etc, and that this disruption appears to be what helps many people overcome ingrained patterns of negative thinking. The trouble appears to be that this state of epiphany following a psychedelic experience is not permanent, I have heard figures of six months following a psylocibin experience. Therefore, to keep achieving this affect repeated doses would be needed which may have a negative effect, further studies may tell. However it may provide time window to allow other treatments to work, in the same sense that antidepressants are supposed to be paired with therapy. I'd always heard that psychedelic experience provides similar effects to a deep meditative experience and thought "well, who wants to do that boring meditation when you can just take a magic potion and be done with it" ? However, meditative and mindfulness practices, for those it helps, would seem to be far more sustainable than any drugs. I have lately been reading The Craving Mind by Judson Brewer, and the RAIN (Recognise, Acknowledge, Investigate, Note) framework it prescribes has been useful in reducing negative ruminations and undesired cravings. Currently I am completely sober from all substances and am using mindfulness and meditative practice to find a more sustainable path to peace within myself. I have no desire to take any substance which would jeopardise this.