4 ms·

Afterglow is a layman's term but tells you nothing of the science. After the high does of amines (serotonin analog) which results in a drastic change serotonin

Afterglow is a layman's term but tells you nothing of the science. After the high does of amines (serotonin analog) which results in a drastic change serotonin receptor densities. It takes a while fro these receptors densities to return to normal. DMT behaves as an agonist at both 5-HT2A and 5-HT2C receptors. There is nothing more to the magic than that. P.S. I have the same experience as being on DMT and I do not take DMT and for some reason I am on disability for it. So tell me again how this is beneficial?

CommitSyn 4y ago
I'm confused. What are you on disability for? Surely not for using DMT...
- lalopalota 4y ago
  Sounds like they are on disability because they experience DMT-like effects without taking DMT.
  - FollowingTheDao 4y ago
    Yes. I have schizo-affective bipolar disorder and I often have hallucinations.
    - CommitSyn 4y ago
      I see in another comment you said you cured your schizo-affective Bipolar disorder without medication. Do you mind if I ask how you did that? I have a condition (probable personality disorder with extreme anxiety) and I've been taking methadone to get off of opioids for about 4 years now, and I noticed that when I go down on my dose, my symptoms start to flare up. So in essence I'm keeping it in check with the same class of drugs I was using to self-medicate with. I have done DMT and it did do wonders for me (went from daily suicidal ideation to almost no suicidal thoughts in almost a decade) but I think there has to be more.
bordercases 4y ago
If the phenomena is complex even when the mechanism is glossable, you are missing out in descriptive detail when you imply it is "just" an agonist on those receptors. That itself should be mind-boggling. You have those receptors in your stomach.
hombre_fatal 4y ago
Being able to dip into an experience at one’s leisure is worlds different than being stuck with that experience due to a long term condition.
- FollowingTheDao 4y ago
  Why? I mean I can make up all the stories I want, right? I can call myself a shaman or a mystic, but no one cares. But you get McKenna tripping out wholly on drugs and somehow he is special and knows everything? I know my worth but no one cares, they will not listen to me because of my overly creative mind. Very few people here can understand the connection I make. It made me a better person because it had to. It forced me to self reflect. Why do you all need drugs to do that?
sva_ 4y ago
Since you try to bring scientific rigor into the discussion, could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities? Having taken several neuroscience classes, I think that claim is a gross oversimplification and an overly reductionist take on the incredibly complex topic at hand. > So tell me again how this is beneficial? I can't answer that question as I have made no statement about any purported benefits or lack thereof.
- FollowingTheDao 4y ago
  > could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities? When someone takes prozac and tries to stop, they have withdrawal effects. Prozac increases serotonin which increases receptor density. https://link.springer.com/article/10.1023/A:1014862808126 https://link.springer.com/article/10.1023/A:1014862808126 Why should this be any different from DMT? I have been studying neurobiology for 20 years. I thought a lot of things that I found out were wrong.
  - sva_ 4y ago
    > https://link.springer.com/article/10.1023/A:1014862808126 https://link.springer.com/article/10.1023/A:1014862808126 1. The results of this study are about long-term treatment, not a single dose. 2. The study makes absolutely zero claims about the epiphenomenal effects of receptor site increases/decreases, as far as I can see. That is your interpretation (with no evidence.) Sure, people describe withdrawal effects after quitting a drug that made them feel good, and there might be a correlation with decreasing receptor sites and those withdrawal symptoms, but you have not established any causal links, the main point I asked you about. 3. In the original comment you associated the generally positive effects that the OOP described as a consequence of decreasing serotonin receptor sites. Yet then you make a claim based on this study that decreasing receptor sites cause negative withdrawal effects. It very much seems like those two claims contradict themselves? Honestly a bit confused here what you're trying to say. > I have been studying neurobiology for 20 years. Well that's impressive. May I ask what your h-index is?

CommitSyn 4y ago

I'm confused. What are you on disability for? Surely not for using DMT...

lalopalota 4y ago
Sounds like they are on disability because they experience DMT-like effects without taking DMT.
- FollowingTheDao 4y ago
  Yes. I have schizo-affective bipolar disorder and I often have hallucinations.
  - CommitSyn 4y ago
    I see in another comment you said you cured your schizo-affective Bipolar disorder without medication. Do you mind if I ask how you did that? I have a condition (probable personality disorder with extreme anxiety) and I've been taking methadone to get off of opioids for about 4 years now, and I noticed that when I go down on my dose, my symptoms start to flare up. So in essence I'm keeping it in check with the same class of drugs I was using to self-medicate with. I have done DMT and it did do wonders for me (went from daily suicidal ideation to almost no suicidal thoughts in almost a decade) but I think there has to be more.

bordercases 4y ago

If the phenomena is complex even when the mechanism is glossable, you are missing out in descriptive detail when you imply it is "just" an agonist on those receptors. That itself should be mind-boggling. You have those receptors in your stomach.

hombre_fatal 4y ago

Being able to dip into an experience at one’s leisure is worlds different than being stuck with that experience due to a long term condition.

FollowingTheDao 4y ago
Why? I mean I can make up all the stories I want, right? I can call myself a shaman or a mystic, but no one cares. But you get McKenna tripping out wholly on drugs and somehow he is special and knows everything? I know my worth but no one cares, they will not listen to me because of my overly creative mind. Very few people here can understand the connection I make. It made me a better person because it had to. It forced me to self reflect. Why do you all need drugs to do that?

sva_ 4y ago

Since you try to bring scientific rigor into the discussion, could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities? Having taken several neuroscience classes, I think that claim is a gross oversimplification and an overly reductionist take on the incredibly complex topic at hand. > So tell me again how this is beneficial? I can't answer that question as I have made no statement about any purported benefits or lack thereof.

FollowingTheDao 4y ago
> could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities? When someone takes prozac and tries to stop, they have withdrawal effects. Prozac increases serotonin which increases receptor density. https://link.springer.com/article/10.1023/A:1014862808126 https://link.springer.com/article/10.1023/A:1014862808126 Why should this be any different from DMT? I have been studying neurobiology for 20 years. I thought a lot of things that I found out were wrong.
- sva_ 4y ago
  > https://link.springer.com/article/10.1023/A:1014862808126 https://link.springer.com/article/10.1023/A:1014862808126 1. The results of this study are about long-term treatment, not a single dose. 2. The study makes absolutely zero claims about the epiphenomenal effects of receptor site increases/decreases, as far as I can see. That is your interpretation (with no evidence.) Sure, people describe withdrawal effects after quitting a drug that made them feel good, and there might be a correlation with decreasing receptor sites and those withdrawal symptoms, but you have not established any causal links, the main point I asked you about. 3. In the original comment you associated the generally positive effects that the OOP described as a consequence of decreasing serotonin receptor sites. Yet then you make a claim based on this study that decreasing receptor sites cause negative withdrawal effects. It very much seems like those two claims contradict themselves? Honestly a bit confused here what you're trying to say. > I have been studying neurobiology for 20 years. Well that's impressive. May I ask what your h-index is?