4 ms·

I would advice against prolonged use or using it often. I have seen people around me change their behavior irrationally and erratically, and not for the good, a

by prox 4y ago

I would advice against prolonged use or using it often. I have seen people around me change their behavior irrationally and erratically, and not for the good, as in not being able to regulate their emotions in a sensible fashion. So while fascinating perhaps, I don’t think it is always used responsibly.

jallasprit 4y ago
As seems to be the case with most things. Everything done in moderation. Overconsumption of anything will bring harm in different ways. I also believe some changes to ones personality is less than ideal, but more ideal than say, chronic opioid/stimulant/etc use over time
aziaziazi 4y ago
Many would say the same about friends taking antidepressants as IMA, ISRS, ATC… or others DANGEROUS stuff as opioids. An average 2023 pharma shopping bag is highly dangerous when not used responsibly ! Moreover, DMT does not induce any addiction, which may be a cause of its absence on drug dealers and pharmacorps shelves. We should celebrate studies of medecines that have a chance to help people without damaging them.
- reportgunner 4y ago
  Sounds like DMT can damage them as well. https://pubmed.ncbi.nlm.nih.gov/26166234/ https://pubmed.ncbi.nlm.nih.gov/26166234/
  - jallasprit 4y ago
    Correlation, not causation: > Laboratory studies revealed elevated creatinine kinase level indicative of rhabdomyolysis. Rhabdomyolysis is associated with a range of medications, drugs and toxins. Many medications increase the risk of rhabdomyolysis.[12] The most important ones are:[4][9][11] Statins and fibrates, both used for elevated cholesterol, especially in combination; cerivastatin (Baycol) was withdrawn in 2001 after numerous reports of rhabdomyolysis.[13] Other statins have a small risk of 0.44 cases per 10,000 person-years.[8] Previous chronic kidney disease and hypothyroidism increase the risk of myopathy due to statins. It is also more common in the elderly, those who are severely disabled, and when statins are used in combination with particular other medicines, such as ciclosporin.[13][8] Antipsychotic medications may cause neuroleptic malignant syndrome, which can cause severe muscle rigidity with rhabdomyolysis and hyperpyrexia Neuromuscular blocking agents used in anesthesia may result in malignant hyperthermia, also associated with rhabdomyolysis Medications that cause serotonin syndrome, such as SSRIs Medications that interfere with potassium levels, such as diuretics Poisons linked to rhabdomyolysis are heavy metals and venom from insects or snakes.[4] Hemlock may cause rhabdomyolysis, either directly or after eating quail that have fed on it.[4][11] Fungi such as Russula subnigricans and Tricholoma equestre are known to cause rhabdomyolysis.[14] Haff disease is rhabdomyolysis after consuming fish; a toxic cause is suspected but has not been proven.[15] Drugs of recreational use, including: alcohol, amphetamine, cocaine, heroin, ketamine and MDMA (ecstasy)[4][11]
  - deleted 4y ago
    [deleted]
  - FollowingTheDao 4y ago
    Yes, that is because they both effect serotonin and serotonin receptor density. https://link.springer.com/article/10.1023/A:1014862808126 https://link.springer.com/article/10.1023/A:1014862808126
LilBytes 4y ago
Everything in moderation, especially moderation.
mistermann 4y ago
"Sensible" is a function of the frame of reference (culture, era, religion, profession, upbringing, ingested information/"facts", etc) of the observer.
462436347 4y ago
> I have seen people around me change their behavior irrationally and erratically, and not for the good, as in not being able to regulate their emotions in a sensible fashion Their hearts have probably changed as well, and likewise, not for the good.
FollowingTheDao 4y ago
This is typical drug "addiction" behavior. I call it a "negative addiction" (copyright me). In a positive addiction you see the drug that makes you feel better. In a negative addiction, the drug leaves you feeling worse but there is not craving for it. This occurs with drugs that do not affect dopamine or the dopamine receptors.

by prox 4y ago

jallasprit 4y ago

As seems to be the case with most things. Everything done in moderation. Overconsumption of anything will bring harm in different ways. I also believe some changes to ones personality is less than ideal, but more ideal than say, chronic opioid/stimulant/etc use over time

aziaziazi 4y ago

Many would say the same about friends taking antidepressants as IMA, ISRS, ATC… or others DANGEROUS stuff as opioids. An average 2023 pharma shopping bag is highly dangerous when not used responsibly ! Moreover, DMT does not induce any addiction, which may be a cause of its absence on drug dealers and pharmacorps shelves. We should celebrate studies of medecines that have a chance to help people without damaging them.

reportgunner 4y ago
Sounds like DMT can damage them as well. https://pubmed.ncbi.nlm.nih.gov/26166234/ https://pubmed.ncbi.nlm.nih.gov/26166234/
- jallasprit 4y ago
  Correlation, not causation: > Laboratory studies revealed elevated creatinine kinase level indicative of rhabdomyolysis. Rhabdomyolysis is associated with a range of medications, drugs and toxins. Many medications increase the risk of rhabdomyolysis.[12] The most important ones are:[4][9][11] Statins and fibrates, both used for elevated cholesterol, especially in combination; cerivastatin (Baycol) was withdrawn in 2001 after numerous reports of rhabdomyolysis.[13] Other statins have a small risk of 0.44 cases per 10,000 person-years.[8] Previous chronic kidney disease and hypothyroidism increase the risk of myopathy due to statins. It is also more common in the elderly, those who are severely disabled, and when statins are used in combination with particular other medicines, such as ciclosporin.[13][8] Antipsychotic medications may cause neuroleptic malignant syndrome, which can cause severe muscle rigidity with rhabdomyolysis and hyperpyrexia Neuromuscular blocking agents used in anesthesia may result in malignant hyperthermia, also associated with rhabdomyolysis Medications that cause serotonin syndrome, such as SSRIs Medications that interfere with potassium levels, such as diuretics Poisons linked to rhabdomyolysis are heavy metals and venom from insects or snakes.[4] Hemlock may cause rhabdomyolysis, either directly or after eating quail that have fed on it.[4][11] Fungi such as Russula subnigricans and Tricholoma equestre are known to cause rhabdomyolysis.[14] Haff disease is rhabdomyolysis after consuming fish; a toxic cause is suspected but has not been proven.[15] Drugs of recreational use, including: alcohol, amphetamine, cocaine, heroin, ketamine and MDMA (ecstasy)[4][11]
- deleted 4y ago
  [deleted]
- FollowingTheDao 4y ago
  Yes, that is because they both effect serotonin and serotonin receptor density. https://link.springer.com/article/10.1023/A:1014862808126 https://link.springer.com/article/10.1023/A:1014862808126

LilBytes 4y ago

Everything in moderation, especially moderation.

mistermann 4y ago

"Sensible" is a function of the frame of reference (culture, era, religion, profession, upbringing, ingested information/"facts", etc) of the observer.

462436347 4y ago

> I have seen people around me change their behavior irrationally and erratically, and not for the good, as in not being able to regulate their emotions in a sensible fashion Their hearts have probably changed as well, and likewise, not for the good.

FollowingTheDao 4y ago

This is typical drug "addiction" behavior. I call it a "negative addiction" (copyright me). In a positive addiction you see the drug that makes you feel better. In a negative addiction, the drug leaves you feeling worse but there is not craving for it. This occurs with drugs that do not affect dopamine or the dopamine receptors.