No, the fact that amyloid-beta or at least its precursor protein APP is causative in Alzheimer's disease is based on very solid science, with a huge amount of g

No, the fact that amyloid-beta or at least its precursor protein APP is causative in Alzheimer's disease is based on very solid science, with a huge amount of genetic evidence behind it. Lecanemab an antibody that binds to amyloid-beta, is disease-modifying and slows down cognitive deterioration. The paper from 2006 carried no significance for any of this and it had only minor impact on Alzheimer's disease research. There has been discussion to whether the plaques of amyloid-beta protein are disease-causing or not. I, as probably most others, believe the plaques as such are non-causative, and that the damage from amyloid-beta happens when amyloid-beta is in a soluble state.