4 ms·

This article is very short on details. >"Indeed, high blood levels of lipopolysaccharides and certain short-chain fatty acids (acetate and valerate) were assoc

by Jerry2 4y ago

This article is very short on details. >"Indeed, high blood levels of lipopolysaccharides and certain short-chain fatty acids (acetate and valerate) were associated with both large amyloid deposits in the brain. Any indications which bacteria produces these amyloids?

blakesterz 4y ago
That was my question to... This discovery paves the way for potentially highly innovative protective strategies -- through the administration of a bacterial cocktail, for example, or of pre-biotics to feed the "good" bacteria in our intestine. Do we know what GOOD bacteria are or what diet to follow to get them where we want them? Do those same GOOD bacteria help with other things like heart disease?
- CommanderData 4y ago
  I did some reading on 'good bacteria' for bone health and my take away was it can depend person to person. I wouldn't be surprised if there isn't a one sized fits all here. Probably having a big diverse population is better than shooting yourself with a few strains, as we get older we have less diversity of gut bacteria and interesting the younger have the opposite. I'm unsure how? we're generally consuming the same foods, if not better quality comparatively to younger people?
  - srcreigh 4y ago
    Antibiotics, poor diet over time. I wonder if alcohol has any effect too.
  - giraffe_lady 4y ago
    Older people do drop foods and change diet in response to other things that change with age, like allergies, dentition, digestion, blood pressure or diabetes. Old people aren't just young people with years you accumulate stuff and change your life in response. I heavily doubt that's the main reason for this difference, but old people diets are a healthcare trope for a reason.
tomohelix 4y ago
I doubt there is a concrete answer. Many bacteria produce amyloids as a normal part of their body. Amyloids are just one specific type of protein fold stacking on each other, and it is so, so common. Same thing with SCFAs, they are normally part of the metabolic cycle of many bacteria. Tracking down one of them is nearly impossible from something as complex as the gut microbiome.

by Jerry2 4y ago

blakesterz 4y ago

That was my question to... This discovery paves the way for potentially highly innovative protective strategies -- through the administration of a bacterial cocktail, for example, or of pre-biotics to feed the "good" bacteria in our intestine. Do we know what GOOD bacteria are or what diet to follow to get them where we want them? Do those same GOOD bacteria help with other things like heart disease?

CommanderData 4y ago
I did some reading on 'good bacteria' for bone health and my take away was it can depend person to person. I wouldn't be surprised if there isn't a one sized fits all here. Probably having a big diverse population is better than shooting yourself with a few strains, as we get older we have less diversity of gut bacteria and interesting the younger have the opposite. I'm unsure how? we're generally consuming the same foods, if not better quality comparatively to younger people?
- srcreigh 4y ago
  Antibiotics, poor diet over time. I wonder if alcohol has any effect too.
- giraffe_lady 4y ago
  Older people do drop foods and change diet in response to other things that change with age, like allergies, dentition, digestion, blood pressure or diabetes. Old people aren't just young people with years you accumulate stuff and change your life in response. I heavily doubt that's the main reason for this difference, but old people diets are a healthcare trope for a reason.

tomohelix 4y ago

I doubt there is a concrete answer. Many bacteria produce amyloids as a normal part of their body. Amyloids are just one specific type of protein fold stacking on each other, and it is so, so common. Same thing with SCFAs, they are normally part of the metabolic cycle of many bacteria. Tracking down one of them is nearly impossible from something as complex as the gut microbiome.