Your business being based on strong personal relationships with people/businesses local to you is the first one off the top of my head. Strong geographical ties

Your business being based on strong personal relationships with people/businesses local to you is the first one off the top of my head. Strong geographical ties (family, etc) of the founders/employees is second. YC probably wouldn't be interested in funding such a startup, and rightly so for them. But there's loads of startups that aren't YC's niche, all of them swept away by your statement I quoted.