5 ms·
There is no regulation for the % of each isomer in the product. Do you have a source? The FDA label says it's 50% d,l-amphetamine (50/50) plus 50% d-amphetmai
by refurb 4y ago
There is no regulation for the % of each isomer in the product.
Do you have a source? The FDA label says it's 50% d,l-amphetamine (50/50) plus 50% d-amphetmaine, so you end up with a 3:1 ratio of dextroamphetamine to levoamphetamine.
Why would a manufacturer do more work to change the 50/50 mix? And why would it vary from batch to batch? The FDA has requirements on manufacturing that each lot is made to the same specifications.
The more reasonable explanation is that the binding agents changed, which may change the rate at which the drug dissolves and is absorbed.
This actually happened a while back with generic bupropion. Generic manufacturers made a 300 mg version, which had 300 mg of drug in it. However, the medicine was absorbed much more quickly leading to a rash of side effect complaints from patients. The FDA eventually recalled the drug.
If you want to read how generics are tested and approved, Derek Lowe did a nice blog post on it: https://www.science.org/content/blog-post/generic-wellbutrin-problem-whose-fault-it https://www.science.org/content/blog-post/generic-wellbutrin...
"In that study, the results of which became available in August 2012, Budeprion XL 300 mg failed to demonstrate bioequivalence to Wellbutrin XL 300 mg."
- DontchaKnowit 4y agoFrankly, ive done all kinds of amphetamines, ingested them by every means except iv. It is not a matter of the rate of absorption. The experience is qualitatively different. Perhaps I am wrong about the stereoisomer mixture - but amphetamine salts are NOT racemic in the first place - so some amount of seperation is happening- I am quite certain that the different brands do not contain the same proportions.
- PragmaticPulp 4y ago> Frankly, ive done all kinds of amphetamines, ingested them by every means except iv. I hate to say it, but recreational amphetamine use and abuse via different ROAs is very likely the explanation for why amphetamine feels different for you now. Abusing stimulants, especially through different routes of ingestion, will cause various forms of tolerance (as I'm sure you're well aware).
- DontchaKnowit 4y agoAmphetamines dont "feel different to me now" - different preperations of the same drug feel markedly different. Name brand adderall and sandoz generic feel the same as they always have. Actavis feels like I am geeked the fuck out. Honestly feels quite similar to the effect of eating the cotton out of benzedrex inhalers (please, no judgement, I was very interested in drug experimentation as a youth) I did look into the stereoisomers of generics per your comment - you are correct, the fda does regulate the specific enantiomers present in a mediciation. So I am at a loss. I am certain Actavis specifically is chemically different. Perhaps there is an inactive ingredient that is modulating the effects? Or perhaps Actavis is just lying to the FDA. I would love to find some 3rd party which does evaluations of chemical makeup for generics. Was unable to find such a thing, if you know of something like that, id be very interested.
- LorenPechtel 4y agoI do believe not enough attention is paid to the "inactive" ingredients. We have had too many reports of things like finding vitamin tablets in the septic tank--they contained the right stuff but didn't dissolve like they were supposed to.