4 ms·

I specifically used "relevant interactions" to rule out "modelling just a single cell's interactions with its environments" but who knows how deep you need to g

I specifically used "relevant interactions" to rule out "modelling just a single cell's interactions with its environments" but who knows how deep you need to go to have an accurate model. > we're studying an "emergent" phenomenon It's like saying that mapping all cells in human organism to addresses in memory will give us emergent human inside computer. But still at abstract layer we just do not have a model of a working brain, we only have maps of neurons, not an actual "algorithm" or a model of all relevant environment interactions needed for a working brain or a set of "abstract instructions" needed for it to work. I think you are over optimistic about current state of our knowledge if we can't even model organism with few thousand neurons accurately. Imagine trying to do that for tens of billions of neurons and trillions of synapses, especially that we know brain doesn't work like an ANN at all[1]. 1. https://www.nature.com/articles/s41583-020-0277-3/ https://www.nature.com/articles/s41583-020-0277-3/

groestl 4y ago
> It's like saying that mapping all cells in human organism to addresses in memory will give us emergent human inside computer. Sounds more like they're saying: a knee is a knee, it doesn't have any magical properties. Build something that bends, and it will behave like a knee. I don't know how true that is, obviously.
- actionfromafar 4y ago
  It's not totally true even for knees. Artificial replacement knees aren't as good as original knees.
  - nicoburns 4y ago
    I guess the point is that we might be able to simulate an artificial knee equivalent for neurons. It won’t be as good as a real knee, but it might still be useful.
  - epgui 4y ago
    I’d argue they’re better (in some ways), given that they’re “dead” material as opposed to functional tissue. Human knees don’t last nearly as long when the tissue is dead.
    - meindnoch 4y ago
      Lol. That's an interesting definition of "better". If you're active, knee implants have to be replaced after 15-20 years, because they detach from the bone. Knee implants can harbor pockets of infections because they don't have an immune system. They are also more prone to dislocations. They are objectively inferior to a healthy organic knee.
      - epgui 4y ago
        Yes, my comment was made a bit in jest. I think everyone will agree that after an arthroplasty, your quality of life is not as good as it was before. But most of the reasons why artificial knees are not as good as the real deal have to do with the fact that they're made of inert (albeit fancy) materials. They don't have the ability to continually heal and do tissue remodelling, which is what real tissue does. I feel very optimistic when I think about this: we're limited, but I think it's absolutely wonderful what we're able to do.
    - abudabi123 4y ago
      You should be able to relocate the instruction pointers in the stem cell's dna to patch in place the original knee with new living original knee. Hope that reality isn't 50-years or more into the distant future.

groestl 4y ago

> It's like saying that mapping all cells in human organism to addresses in memory will give us emergent human inside computer. Sounds more like they're saying: a knee is a knee, it doesn't have any magical properties. Build something that bends, and it will behave like a knee. I don't know how true that is, obviously.

actionfromafar 4y ago
It's not totally true even for knees. Artificial replacement knees aren't as good as original knees.
- nicoburns 4y ago
  I guess the point is that we might be able to simulate an artificial knee equivalent for neurons. It won’t be as good as a real knee, but it might still be useful.
- epgui 4y ago
  I’d argue they’re better (in some ways), given that they’re “dead” material as opposed to functional tissue. Human knees don’t last nearly as long when the tissue is dead.
  - meindnoch 4y ago
    Lol. That's an interesting definition of "better". If you're active, knee implants have to be replaced after 15-20 years, because they detach from the bone. Knee implants can harbor pockets of infections because they don't have an immune system. They are also more prone to dislocations. They are objectively inferior to a healthy organic knee.
    - epgui 4y ago
      Yes, my comment was made a bit in jest. I think everyone will agree that after an arthroplasty, your quality of life is not as good as it was before. But most of the reasons why artificial knees are not as good as the real deal have to do with the fact that they're made of inert (albeit fancy) materials. They don't have the ability to continually heal and do tissue remodelling, which is what real tissue does. I feel very optimistic when I think about this: we're limited, but I think it's absolutely wonderful what we're able to do.
  - abudabi123 4y ago
    You should be able to relocate the instruction pointers in the stem cell's dna to patch in place the original knee with new living original knee. Hope that reality isn't 50-years or more into the distant future.