5 ms·

TLDR: Lion's mane mushrooms, not magic ones or the common white mushrooms. Link to full text of paper: Hericerin derivatives activates a pan-neurotrophic path

TLDR: Lion's mane mushrooms, not magic ones or the common white mushrooms. Link to full text of paper: Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767 https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767

EngManagerIsMe 4y ago
... in vitro and in 40 male mice.
- fwlr 4y ago
  The effects of lions mane mushroom has been studied in humans before (https://examine.com/supplements/lionsmane/#research-breakdown https://examine.com/supplements/lionsmane/#research-breakdow...). This is a study specifically of the mechanism by which those effects arise.
  - cpncrunch 4y ago
    The one human trial there shows no difference between active and placebo groups. https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231...
    - dymk 4y ago
      > Our results show that HE intake has the possibility to reduce depression and anxiety and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus. No, it says that there is a possible difference, but the mechanism is not what they thought it might be
      - cpncrunch 4y ago
        The abstract is just hype. Read the full text. There was no difference between groups. The study failed!
    - fwlr 4y ago
      Fantastic! With mice in vitro you had no idea if there was an effect, with this study you have evidence there is no effect!
- deleted 4y ago
  [deleted]
metadat 4y ago
How to best ingest them? And at what dosage? TFA mentions something about "extract" but is light on further details.
- deleted 4y ago
  [deleted]
- gopalv 4y ago
  I saw them in Whole Foods[1] this week, in their own store brand version. My friend who took it said it causes headaches in the beginning, but that either their tolerance picked up or it was just an initial effect of the supplement. The odd thing about a supplement which has studies coming out about them is that, if it really works in a drug specific way, then FDA will regulate it and remove it off the supplement shelf like what happened with NMN. [1] - https://www.wholefoodsmarket.com/product/365-by-whole-foods-market-lions-mane-90-capsules-b08lj443yp https://www.wholefoodsmarket.com/product/365-by-whole-foods-...
  - TedDoesntTalk 4y ago
    1/2 gram per pill? Seems rather small compared to eating, well, a few full sized mushrooms per day.
- deleted 4y ago
  [deleted]
- kirykl 4y ago
  Oriveda has a very high quality water based fruiting body and alcohol based mycelium extract combo

EngManagerIsMe 4y ago

... in vitro and in 40 male mice.

fwlr 4y ago
The effects of lions mane mushroom has been studied in humans before (https://examine.com/supplements/lionsmane/#research-breakdown https://examine.com/supplements/lionsmane/#research-breakdow...). This is a study specifically of the mechanism by which those effects arise.
- cpncrunch 4y ago
  The one human trial there shows no difference between active and placebo groups. https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231...
  - dymk 4y ago
    > Our results show that HE intake has the possibility to reduce depression and anxiety and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus. No, it says that there is a possible difference, but the mechanism is not what they thought it might be
    - cpncrunch 4y ago
      The abstract is just hype. Read the full text. There was no difference between groups. The study failed!
  - fwlr 4y ago
    Fantastic! With mice in vitro you had no idea if there was an effect, with this study you have evidence there is no effect!
deleted 4y ago
[deleted]

metadat 4y ago

How to best ingest them? And at what dosage? TFA mentions something about "extract" but is light on further details.

deleted 4y ago
[deleted]
gopalv 4y ago
I saw them in Whole Foods[1] this week, in their own store brand version. My friend who took it said it causes headaches in the beginning, but that either their tolerance picked up or it was just an initial effect of the supplement. The odd thing about a supplement which has studies coming out about them is that, if it really works in a drug specific way, then FDA will regulate it and remove it off the supplement shelf like what happened with NMN. [1] - https://www.wholefoodsmarket.com/product/365-by-whole-foods-market-lions-mane-90-capsules-b08lj443yp https://www.wholefoodsmarket.com/product/365-by-whole-foods-...
- TedDoesntTalk 4y ago
  1/2 gram per pill? Seems rather small compared to eating, well, a few full sized mushrooms per day.
deleted 4y ago
[deleted]
kirykl 4y ago
Oriveda has a very high quality water based fruiting body and alcohol based mycelium extract combo