Consider taking a closer look at your "constant depression" issue. Burnout may in fact be the reason, but what if you come back and realize it wasn't? You say

Consider taking a closer look at your "constant depression" issue. Burnout may in fact be the reason, but what if you come back and realize it wasn't? You say it isn't the specifically the job too... Taking work off could help, but if the job (or working in general) isn't the root issue, taking time off work might not help. You have plenty of savings to afford to spend some of it to figure out. A different question you maybe should be asking is not if you should take the time off, but how to spend that time.