It's an interesting question. The assumption is that it will never (or at least not for a very very long time) make sense to mine or manufacture in space for u

It's an interesting question. The assumption is that it will never (or at least not for a very very long time) make sense to mine or manufacture in space for use on Earth. Mining/Manufacturing in space for use in space will presumably happen in only a very long time. That said; what the bigger issue - for in situ operations, the distance to get the raw materials or just doing anything with the raw materials at all? Is it going to be - we could do anything at all but going all the way past the orbit of Mars is too much trouble - or - Getting to a rock past Mars is easy but it's hard to do anything practical with it (compared to just getting it off Earth presumably) I got no clue as to which way it could go but it doesn't seem a question that answers itself to me.