4 ms·

It's interesting he mentions allergy shots. It sounds like his doctor didn't know about sublingual immunotherapy. It's similarly effective, but much less disrup

It's interesting he mentions allergy shots. It sounds like his doctor didn't know about sublingual immunotherapy. It's similarly effective, but much less disruptive to the ongoings of daily life. Disclaimer: I run Wyndly (https://www.wyndly.com/ https://www.wyndly.com/) a YC-backed startup that uses sublingual immunotherapy, among other allergy treatments, to help people breathe better.

Wagthesam 4y ago
I know about SLIT, but from my research most allergists don't mix in enough to make it comparable to shots. From studies I read you need 30-100x the dose of shots taken in monthly aggregate for it to be comparable. For example Odactra which is fda approved for dust mites is 30x the concentration of a monthly maintenance dose. I am allergic to almost everything, so I imagine it will be too costly to treat properly Also it is much less regulated as its not fda approved, so the quality you are getting is less certain than shots. I would not be surprised if the majority of SLIT use cases in the US are placebo due to cost constraints outside of the fda approved tablets covered by insurance. Yes studies is one thing and its shown clearly that its comparable, but you need the right concentrations TBH I am skeptical of startups that operate in this type of environment as theres not enough oversight. For me to be comfortable it would need to be very transparent what is going into the mix source: https://fairfieldcountyallergy.com/whats-the-story-on-allergy-drops/ https://fairfieldcountyallergy.com/whats-the-story-on-allerg... "Sublingual immunotherapy is not currently covered by health insurance companies in the United States because it is ineffective as it is done here"
- ahstilde 4y ago
  I agree with you -- the protocol is what matters. Your concern about the dosage applies to allergy shots, too, however. At Wyndly, our protocol follows the academic research. I'll work on making this more explicit.

Wagthesam 4y ago

I know about SLIT, but from my research most allergists don't mix in enough to make it comparable to shots. From studies I read you need 30-100x the dose of shots taken in monthly aggregate for it to be comparable. For example Odactra which is fda approved for dust mites is 30x the concentration of a monthly maintenance dose. I am allergic to almost everything, so I imagine it will be too costly to treat properly Also it is much less regulated as its not fda approved, so the quality you are getting is less certain than shots. I would not be surprised if the majority of SLIT use cases in the US are placebo due to cost constraints outside of the fda approved tablets covered by insurance. Yes studies is one thing and its shown clearly that its comparable, but you need the right concentrations TBH I am skeptical of startups that operate in this type of environment as theres not enough oversight. For me to be comfortable it would need to be very transparent what is going into the mix source: https://fairfieldcountyallergy.com/whats-the-story-on-allergy-drops/ https://fairfieldcountyallergy.com/whats-the-story-on-allerg... "Sublingual immunotherapy is not currently covered by health insurance companies in the United States because it is ineffective as it is done here"

ahstilde 4y ago
I agree with you -- the protocol is what matters. Your concern about the dosage applies to allergy shots, too, however. At Wyndly, our protocol follows the academic research. I'll work on making this more explicit.