I've been running these patches to play around with them and it seems pretty good; layered windows (WS_EX_LAYERED) work great, and the issue you would have with

I've been running these patches to play around with them and it seems pretty good; layered windows (WS_EX_LAYERED) work great, and the issue you would have with non-reparenting X11/XWayland WMs (mostly the mouse cursor being offset) is gone. There's still some minor quirks remaining, so it's not perfect, but a complex program like FL Studio seems to work just fine, as does some games using Wined3d. The only thing I really hit that would be nice to fix is that it appears tablet support isn't in yet, or at least it didn't work for me. Of course, tablet support is a thing I generally wish could be improved in Wine, especially because Windows apps are slowly moving towards more modern APIs than the old wintab32 defacto standard.