4 ms·

The effect size and response of Atomoextine stacks quite badly against stimulants, which are first line treatments. It also targets noradrenaline mostly, with r

The effect size and response of Atomoextine stacks quite badly against stimulants, which are first line treatments. It also targets noradrenaline mostly, with relatively minor effect in dopamine. If it works for you, great, but for many including myself it was a waste of time. I'm not from the US or Europe btw, but if you want a sound complaint against the status quo in the US, I'd argue against the popularity of the Adderall mixture of L and D-amp over LDX (Vyvanse), which seems more effective (only D-amp) and less addictive.

salawat 4y ago
Vyvanse, at least for me, tends to amplify aggressive tendencies to the point I've had my partner comment I scare her. This includes shortening my fuse with people during training, and tolerance for other people making a mistake. All while getting 8 hours or more of sleep a night, actually gaining weight, and having subjectively higher QoL on my end. So no "Adderolling" as @Pigalowda is so fond of criticizing. I get jack and shit out of Straterra in terms of objective therapeutic benefit. Adderall, I have no such aggression amplification problems with, at the cost of needing a substantially higher dose. I'm much more patient and tolerant of frustration, have many fewer ANT's (Automatic Negative Thoughts), and I don't need to take regular breaks to cool off. While Vyvanse undeniably worked for me in terms of increasing my capability to pay attention throughout the day, and as a consequence, get tons done, not only in terms of work, but living a normal life with hobbies; that price tag of inducing eggshell walking among those I love was just too damn high. So I'm back on Adderall... Learning new coping strategies... trying to just get by. Point being, please abstain from painting in broad strokes and assuming just because you may have some pet theory down, that that translates without loss in practice. It doesn't. Not by a long shot.
- mickelsen 4y ago
  I know there are subtle effect differences between the preparations, sorry that I came across that way. In fact what you describe I also experienced with Vyvanse for years and it just toned down in the recent years by staying at a lower dose and then adding an SSRI (which pretty much removed all those 'triggers' I had of berating people, yet not the 'stim look' that people have on their eyes when on stimulants, that only fades out after the 8-12 hours when you become human again) One time I tried Bupropion instead, I got immediately super short fuse, berating people and so on. Reminded me of a boss I hated so much that would grill me over small things on my PRs for hours, rather than moving on quickly. I didn't want to become anything close to that guy so I just stopped. My point is, the studied outcomes are usually just one variable, that ignores a lot of the extra behavioral effects we as patients get in practice, but it's a good pointer in guiding where to aim treatment first for most. And it seems now LDX is being tried first, before Adderall over there in some practices, with the added convenience of making refills easier. Good luck with your journey pal, I only wish it'd be easier for all of us.
  - salawat 4y ago
    Appreciated, and $DEITY bless in your direction as well. Life is hard enough as is for everyone without throwing Schedule II's on top of it, and dealing with all that nonsense.

salawat 4y ago

Vyvanse, at least for me, tends to amplify aggressive tendencies to the point I've had my partner comment I scare her. This includes shortening my fuse with people during training, and tolerance for other people making a mistake. All while getting 8 hours or more of sleep a night, actually gaining weight, and having subjectively higher QoL on my end. So no "Adderolling" as @Pigalowda is so fond of criticizing. I get jack and shit out of Straterra in terms of objective therapeutic benefit. Adderall, I have no such aggression amplification problems with, at the cost of needing a substantially higher dose. I'm much more patient and tolerant of frustration, have many fewer ANT's (Automatic Negative Thoughts), and I don't need to take regular breaks to cool off. While Vyvanse undeniably worked for me in terms of increasing my capability to pay attention throughout the day, and as a consequence, get tons done, not only in terms of work, but living a normal life with hobbies; that price tag of inducing eggshell walking among those I love was just too damn high. So I'm back on Adderall... Learning new coping strategies... trying to just get by. Point being, please abstain from painting in broad strokes and assuming just because you may have some pet theory down, that that translates without loss in practice. It doesn't. Not by a long shot.

mickelsen 4y ago
I know there are subtle effect differences between the preparations, sorry that I came across that way. In fact what you describe I also experienced with Vyvanse for years and it just toned down in the recent years by staying at a lower dose and then adding an SSRI (which pretty much removed all those 'triggers' I had of berating people, yet not the 'stim look' that people have on their eyes when on stimulants, that only fades out after the 8-12 hours when you become human again) One time I tried Bupropion instead, I got immediately super short fuse, berating people and so on. Reminded me of a boss I hated so much that would grill me over small things on my PRs for hours, rather than moving on quickly. I didn't want to become anything close to that guy so I just stopped. My point is, the studied outcomes are usually just one variable, that ignores a lot of the extra behavioral effects we as patients get in practice, but it's a good pointer in guiding where to aim treatment first for most. And it seems now LDX is being tried first, before Adderall over there in some practices, with the added convenience of making refills easier. Good luck with your journey pal, I only wish it'd be easier for all of us.
- salawat 4y ago
  Appreciated, and $DEITY bless in your direction as well. Life is hard enough as is for everyone without throwing Schedule II's on top of it, and dealing with all that nonsense.