3 ms·
The LD is for Low Dose and it has a short half life of 4 hours, though sensitive can vary by an order of magnitude so how long it lasts can depend. Typically pe
by cjbgkagh 4y ago
The LD is for Low Dose and it has a short half life of 4 hours, though sensitive can vary by an order of magnitude so how long it lasts can depend. Typically people start low and slowly build up. You don't notice the initial effects (unless you're unfortunate enough to need opioids during that time), it's the subsequent bodies reaction overnight that has the real effect. Most healthy people don't notice anything good or bad. Sick people can get a variety of effects and some quite strong but very rarely an emergency.
Anecdotally it appears that if you get a strong effect then it is likely it'll be more beneficial long term. Most common effects are nausea which generally subsides in a few weeks, extremely vivid dreams that you can remember which lasts longer. Basically low grade serotonin sickness and perhaps some dopamine dysregulation - some people do get dopamine surges. It helps normalize neurotransmitter levels and your brain might not be used to it. Usually you sleep less but feel more refreshed. I had one of the rarer reactions which was extreme energy, I started LDN for ME/CFS and thought it had cured me and that I now had a new problem of too much energy. Unfortunately it wore off after a few weeks, but it did plateau to a higher baseline.
- heavyset_go 4y agoNaltrexone metabolizes into methylnaltrexone which lasts longer in the blood and has stronger but slightly different binding profiles than its parent. Is the response from LDN the result of naltrexone, its metabolites or both? I ask because I'm genuinely curious, I'm ignorant of its use for this condition.
- cjbgkagh 4y agoI’ve read at these doses it lasts < 4 hrs but I don’t know the mechanism. It is usually taken at night an hour before going to bed and the post inhibition reaction can be felt the same night during sleep so it must be a matter of hours.
- cjbgkagh 4y agoI should add LDN can normalize thyroid function so if someone is on medication it’ll likely need to be adjusted. And the dreams are next level crazy vivid, it’s probably the most common complaint. Sometimes it can be hard to go to sleep knowing there is a dragon waiting to eat you again. There can be a dissociative feeling when you wake up as you try to work out what was real and what isn’t. Was I really just storming the beaches in Normandy? Hmm seems unlikely, but it feels like I was just there.
- treeman79 4y agoOh yes. I forgot how vivid the dreams were. Those calmed down after a few months for me