Also from the article: > Though a certain amount of lean loss is inevitable with significant weight reduction (usually about 25% of total weight loss) The just

Also from the article: > Though a certain amount of lean loss is inevitable with significant weight reduction (usually about 25% of total weight loss) The justification is provided: this is nearly double the lean body mass loss usually seen in drastic weight loss. Yes, 0% is impossible, but this is worryingly high. It might be OK in younger individuals who have a ton of fat mass to lose, and they might gain any lean body mass back. But in older individuals that are already having a hard time exercising, it's unlikely that lean body mass will ever come back. Makes me think these drugs should probably be a measure of last resort. Unless more studies defuse this.