3 ms·

Making GLP-1 agonists and related drugs (ozempic, mounjaro) cheaply/widely available seems like it would be excellent public policy.

• exfatloss 4y ago
  It seems that they also make you lose tons of lean mass. Normal diets you lose 25% of the lost weight in lean, these seem more like 40%. https://peterattiamd.com/the-downside-of-glp-1-receptor-agonists/ https://peterattiamd.com/the-downside-of-glp-1-receptor-agon...
  • aantix 4y ago
    “Lean mass loss was 2.6% versus 10.9%. Those on tirzepatide had about a threefold greater reduction in fat mass than lean mass, resulting in an overall improvement in body composition. Fat mass as a proportion of overall body mass decreased from 46.8% to 44.7% with placebo, compared with 46.2% to 38.5% with tirzepatide. Similarly, lean mass as a proportion of body mass increased from 50.7% to 52.4% with placebo, compared with 51.0% to 58.1% with tirzepatide. Fat-to-lean mass ratio improved more with tirzepatide than placebo, with greater improvements observed in patients who lost more body weight.” https://www.practiceupdate.com/content/easd-2022-substantial-weight-reduction-with-tirzepatide-produces-multiple-beneficial-metabolic-effects/142614#:~:text=Those%20on%20tirzepatide%20had%20about,%25%20to%2038.5%25%20with%20tirzepatide https://www.practiceupdate.com/content/easd-2022-substantial....
    • exfatloss 4y ago
      Yea, their overall composition still improved of course, because they lost more than 50% in fat. But they lost more lean mass than people who lose that weight in other ways, is my understanding.
  • JamesBarney 4y ago
    In an apples to apples study it showed similar effects to canagliflozin which works through an entirely different pathway. So it's probably not related to GLP-1 but to the speed and effectiveness of weightloss which will most likely be faster than a typical diet. https://pubmed.ncbi.nlm.nih.gov/31897524/ https://pubmed.ncbi.nlm.nih.gov/31897524/