If the weight stays off even after 10 years on the drug, then that's great in my book. Nicotine, caffeine, and bariatric surgery all reduce your appetite in th

If the weight stays off even after 10 years on the drug, then that's great in my book. Nicotine, caffeine, and bariatric surgery all reduce your appetite in the short run, but your body eventually adapts and your weight starts climbing again. Until we've got more than a couple years of data, I'm not holding out hope that this drug won't eventually lose its punch for maintaining a lower weight. The main problem to my mind is that cheap, easy, accessible foods are high in both fat and carbs. Fat is satiating, but super calorie dense. Carbs are less calorie dense, but spike your blood sugar. After your blood sugar levels drop, your body signals that you're hungry again in spite of the fact that you've eaten plenty of calories. So now you're starving again and you've surpassed the number of calories you can reasonably utilize without storing it as fat. Add in the fact that evolution hasn't even begun to catch up with the current situation where calories are not a scarce resource (in the US and similar countries) and your body is screaming to eat while the eating's good. This causes you to comsume way too many calories and nowhere near enough vitamins and minerals. It's a lot of work to eat right anymore. You're working 40 hours a week if you're lucky, you're exhausted and feel like shit and you may not even be able to afford what you need to be eating to maintain a healthy weight. And, just to make things more fun, there's 1000 sources telling you 1000 different things about what you should and shouldn't eat to be healthy. Cholesterol is bad for you - wait, no it isn't. Eat whole grains. No, don't, that's sugar! Eat fruit. Oh no, fruit is basically all sugar. No it isn't, it's full of fiber and that cancels out the sugar. Don't eat fats, except unsaturated fats, but those are calorie dense. Vegetable oil is unsaturated, but that's bad for you too in a different way. It's damn frustrating. If it were as easy as just eating less, no one would be obese. Back to the point of the article, however, I don't think it's as simple as taking a magic pill. How many miracle weight loss drugs have come and gone over the last decade? I'm not holding my breath that this is the one that will turn out to work forever with no severe downsides.