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Yes, but your original comment talks about a concentration of 6 ng/mL in human blood, while the researchers only point out the concentration of the surrounding
by Midfit 4y ago
Yes, but your original comment talks about a concentration of 6 ng/mL in human blood, while the researchers only point out the concentration of the surrounding medium. Perhaps I'm missing something, but you can't compare these two values since you didn't measure the actual concentration of PFAS in the blood stream of the larvae. For all we know it could be lower than 6 ng/mL, right?
- Mistletoe 4y agoThey are also doing studies on human neutrophil cells etc. at 80 uM. The fluid above the cells at 80 uM is a model for cells in blood. You can see in Figure 5 here that the effects are really only seen at the highest non physiological doses. Even their lowest dose of GenX is 2.6 uM which is 2600 nM. I don’t have data for blood levels of GenX but if it is like PFOA that would be 260x higher than any concentration we would expect a neutrophil to ever see. And there is no effect on respiratory burst. https://www.tandfonline.com/doi/epdf/10.1080/1547691X.2023.2176953?needAccess=true&role=button https://www.tandfonline.com/doi/epdf/10.1080/1547691X.2023.2...