Not exactly the same, but reminds me of the saccharin rat studies. Massive dosing (the human equivalent of ~800 diet sodas per day!) plus a physiology that high

Not exactly the same, but reminds me of the saccharin rat studies. Massive dosing (the human equivalent of ~800 diet sodas per day!) plus a physiology that highly concentrates urine led to bladder cancer in rats. Turned out to be completely irrelevant to humans (and now ironically saccharin may be somewhat cancer fighting?). For expedience many of these studies are done at the Maximum Tolerated Dose, which is the amount that does not otherwise outright kill the subjects. It’s understandable that this is useful for magnifying sensitivity but it also leaves them with a tinge of doubt. That compounds with the career benefit for publishing sensational results to generate some bad science (especially frustrating when there are tinfoilers looking to distrust science as it is).