4 ms·
There are two other studies I know of about this: 2022-03-17: “Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-Co
by AlbertoGP 4y ago
There are two other studies I know of about this:
2022-03-17: “Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination”
> “Prolonged detection of vaccine mRNA in LN GCs [lymph node germinal center https://en.wikipedia.org/wiki/Germinal_center https://en.wikipedia.org/wiki/Germinal_center] and spike antigen in LN GCs and blood following SARS-CoV-2 mRNA vaccination”
> “Immunohistochemical staining for spike antigen in mRNA-vaccinated patient LNs varied between individuals but showed abundant spike protein in GCs 16 days post-second dose, with spike antigen still present as late as 60 days post-second dose. ”
https://www.cell.com/cell/fulltext/S0092-8674%2822%2900076-9 https://www.cell.com/cell/fulltext/S0092-8674%2822%2900076-9
2022-06-28: “Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination”
> “A recent ultrasensitive single-molecule assay was however able to detect the S-protein in the plasma of some mRNA-1273 COVID-19 vaccinees at 15 days following injection [12], while in another study, both mRNA and S-protein could be found in axillary LNs after 60 days [13]. Moreover, extracellular vesicles decorated with S-proteins persist up to 4 months after vaccination with BNT162b2 [14]. This raises the possibility that LNP–mRNA complexes remain in circulation for extended periods of time, retaining their ability to induce S-protein expression in contacted cells.”
> “In plasma, mRNA was immediately detectable at just hours following vaccination, remained detectable when sampled at 6 and 15 days (Figure 1A, green), but was below the limit of quantification (LoQ) for one sample at 27 days. Samples from negative controls did not amplify. For subject B3, we observed a similar trend for plasma: vaccine-associated mRNA became detectable immediately after vaccination and remained significantly above the LoQ at day 14 (Figure 1B, green). Interestingly, vaccine mRNA was detected in the cellular fraction up to day 6 in some samples from our cohort, whereas for B3, it was only detectable at one day after vaccination (Figure 1A,B, orange). It has to be noted that the likelihood of detecting vaccine mRNA in the cellular fraction decreased significantly at 24 h from injection, which was in contrast to plasma in which mRNA remained consistently detectable up to day 15 (Figure 1C).”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313234/# https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313234/#
The CDC for instance states in its website:
> “mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. The mRNA from the vaccines is broken down within a few days after vaccination and discarded from the body.”
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/overview-COVID-19-vaccines.html#mrna https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...