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Finding an optimal donor match (via HLA typing) rarely returns many "perfect" matches. Perhaps there are systems that record both the CCR5 mutation and HLA typi

Finding an optimal donor match (via HLA typing) rarely returns many "perfect" matches. Perhaps there are systems that record both the CCR5 mutation and HLA typing, but I'd expect most donor matches, found via registries like https://bethematch.org/ https://bethematch.org/, will not have that information available. I haven't dug into the weeds here (and, for personal emotional reasons, I will not), but I find it hard to believe the medical staffs would have seriously considered "can we find a donor that matches AND will possibly cure the HIV". The diagnosis-to-death timeline for many blood cancers is fast when other treatments don't work. Delaying a transplant by 2 weeks in order to find a slightly more optimal donor seems crazy. (Though I suppose the after-transplant care for someone with HIV might be trickier than those without HIV. But patients will be immune-compromised for at least months post-transplant, so maybe HIV isn't that big of a deal.)

vlz 4y ago
Indeed the article does not mention anything about the donors being chosen with HIV resistance in mind. So there is a good chance of this being a welcome side effect to the cancer treatment but not intentional.
elgenie 4y ago
HIV, in rich countries at least, is a managed condition these days. I'd imagine the only issues would be any sort of interactions between the don't-get-AIDS cocktail and the cancer drugs. Perhaps the matching system has more data in Germany, or perhaps they really are just writing up happy accidents in which they discover that the patient lucked into a CCR5 donor and also already had low enough levels of HIV that the operation made a difference.
Archelaos 4y ago
> I find it hard to believe the medical staffs would have seriously considered "can we find a donor that matches AND will possibly cure the HIV". According to a report of the Tagesschau (belonging to the German public television chanel ARD),[1] the patient had leukemia and the doctors were looking for a fitting donor who was also missing a so-called CCR5 co-receptor. According to the report, people having such a gene mutation can be found especially in Central and Northern Europe. The patient had already been treated in 2018, but is only now considered cured because he has not experienced any HIV symptoms since then. I do not know whether it was relevant in this case, but Germany has a Central Bone Marrow Donor Registry with currently almost 10 million people registered.[2] [1] See https://www.tagesschau.de/wissen/gesundheit/hiv-leukaemie-stammzellspende-101.html https://www.tagesschau.de/wissen/gesundheit/hiv-leukaemie-st... (in German) [2] See https://www.zkrd.de/neue-spender-weiterhin-gesucht/ https://www.zkrd.de/neue-spender-weiterhin-gesucht/ (in German)

vlz 4y ago

Indeed the article does not mention anything about the donors being chosen with HIV resistance in mind. So there is a good chance of this being a welcome side effect to the cancer treatment but not intentional.

elgenie 4y ago

HIV, in rich countries at least, is a managed condition these days. I'd imagine the only issues would be any sort of interactions between the don't-get-AIDS cocktail and the cancer drugs. Perhaps the matching system has more data in Germany, or perhaps they really are just writing up happy accidents in which they discover that the patient lucked into a CCR5 donor and also already had low enough levels of HIV that the operation made a difference.

Archelaos 4y ago

> I find it hard to believe the medical staffs would have seriously considered "can we find a donor that matches AND will possibly cure the HIV". According to a report of the Tagesschau (belonging to the German public television chanel ARD),[1] the patient had leukemia and the doctors were looking for a fitting donor who was also missing a so-called CCR5 co-receptor. According to the report, people having such a gene mutation can be found especially in Central and Northern Europe. The patient had already been treated in 2018, but is only now considered cured because he has not experienced any HIV symptoms since then. I do not know whether it was relevant in this case, but Germany has a Central Bone Marrow Donor Registry with currently almost 10 million people registered.[2] [1] See https://www.tagesschau.de/wissen/gesundheit/hiv-leukaemie-stammzellspende-101.html https://www.tagesschau.de/wissen/gesundheit/hiv-leukaemie-st... (in German) [2] See https://www.zkrd.de/neue-spender-weiterhin-gesucht/ https://www.zkrd.de/neue-spender-weiterhin-gesucht/ (in German)