I think your explanation of how such a resistance might occur is a bit too simplified It's a reasonable assumption that bacteria in the wild have been under pr

I think your explanation of how such a resistance might occur is a bit too simplified It's a reasonable assumption that bacteria in the wild have been under pressure to increase the likelihood of developing resistance genes as an adaptation to organisms producing antibiotics in nature This is a selective pressure that has been applied for millions of years and is likely the reason for anti-biotic resistance being able to develop independently over a relatively short timespan With a synthetic class of antibiotics there would not have been a pressure to increase the likelihood of resistance genes developing against this particular class of drugs As an example, soap and surface disinfectants have been in use for a long time, but to my knowledge resistance to those compounds have not develop in bacteria, despite being used much more frequently than antibiotics